Evidence mapPaperPMID 39796206Full record

ArticleInternational journal of molecular sciences2025

Abamectin Causes Neurotoxicity in Zebrafish Embryos.

Hongying Zhang, Yulong Liu, Yukun Huang, Kaiwen Zhao, Tingting Yu, Youjuan Wu, Zijia Yin, Meifeng Li, Dongming Li, Lihua Fan and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hongying ZhangSchool of Life Science, Nanchang University, Nanchang 330031, China.
Yulong LiuSchool of Life Science, Nanchang University, Nanchang 330031, China.
Yukun HuangSchool of Life Science, Nanchang University, Nanchang 330031, China.
Kaiwen ZhaoSchool of Life Science, Nanchang University, Nanchang 330031, China.
Tingting YuSchool of Life Science, Nanchang University, Nanchang 330031, China.
Youjuan WuSchool of Life Science, Nanchang University, Nanchang 330031, China.
Zijia YinSchool of Life Science, Nanchang University, Nanchang 330031, China.
Meifeng LiInstitute of Pathogenic Microorganism, College of Bioscience and Engineering, Jiangxi Agricultural University, Nanchang 330045, China.
Dongming LiFuzhou Medical College, Nanchang University, Fuzhou 344000, China.
Lihua FanSchool of Life Science, Nanchang University, Nanchang 330031, China.
Xiaowen XuSchool of Life Science, Nanchang University, Nanchang 330031, China.ORCID 0000-0002-8513-3456
Chengyu HuSchool of Life Science, Nanchang University, Nanchang 330031, China.
Shanghong WangSchool of Life Science, Nanchang University, Nanchang 330031, China.

Funding

Chongqing Natural Science Foundation 2024NSCQ-MSX1523Fishery Seed Industry Joint Breeding Project of JiangXi Province 2022yyzygg-01National Key Research and Development Project 2023YFD2400201National Natural Science Foundation of China 32160871, 32260926 and 32460928The Key Research and Development Project of JiangXi Province 20212BBF63029The Natural Science Foundation of Jiangxi Province 20242BAB20316 and 20243BCE51118
6 · The paper itself

Abstract

Abamectin is an insecticide, miticide and nematicide that has been extensively used in agriculture for many years. The excessive use of abamectin inevitably pollutes water and soil and might even cause adverse effects on aquatic biota. However, it is currently unclear how abamectin exposure causes neurotoxicity in aquatic organisms. Herein, the early neural system development was assessed in zebrafish embryos following abamectin exposure. After treatment with a concentration gradient of abamectin (0.055, 0.0825, 0.11 mg/L), the survival rate, average heart rate, pericardial edema area and yolk sac edema were all documented in zebrafish embryos (96 hpf). It was found that after abamectin exposure, embryonic brain development was impaired, and motor behaviors were also affected. The fluorescence intensity was reduced in the transgenic embryos (

Indexed as

Embryo, NonmammalianIvermectinNeurotoxicity SyndromesZebrafishAnimalsAnimals, Genetically ModifiedBrainEmbryonic DevelopmentGene Expression Regulation, DevelopmentalReactive Oxygen SpeciesabamectinIvermectinReactive Oxygen Speciesapoptosisinsecticideneurodevelopmental toxicityoxidative stresszebrafish embryos

Identifiers

PMID39796206
PMCPMC11719719

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.