Evidence map›Paper›PMID 39796211›Full record

ArticleInternational journal of molecular sciences2025

Resting-State EEG Alpha Rhythms Are Related to CSF Tau Biomarkers in Prodromal Alzheimer's Disease.

Claudio Del Percio, Roberta Lizio, Susanna Lopez, Giuseppe Noce, Matteo Carpi, Dharmendra Jakhar, Andrea Soricelli, Marco Salvatore, Görsev Yener, Bahar Güntekin and 27 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Claudio Del PercioDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, 00185 Rome, Italy.
Roberta LizioDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, 00185 Rome, Italy.
Susanna LopezDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, 00185 Rome, Italy.
Giuseppe NoceIRCCS Synlab SDN, 80143 Naples, Italy.ORCID 0000-0003-4324-0293
Matteo CarpiDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6933-5675
Dharmendra JakharDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, 00185 Rome, Italy.
Andrea SoricelliIRCCS Synlab SDN, 80143 Naples, Italy.ORCID 0000-0001-7011-7667
Marco SalvatoreIRCCS Synlab SDN, 80143 Naples, Italy.
Görsev YenerDepartment of Neurology, Faculty of Medicine, Dokuz Eylül University, 35340 İzmir, Turkey.ORCID 0000-0002-7756-4387
Bahar GüntekinResearch Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, 34810 Istanbul, Turkey.
Federico MassaDipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-Infantili (DiNOGMI), Università di Genova, 16132 Genova, Italy.ORCID 0000-0001-5667-204X
Dario ArnaldiDipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-Infantili (DiNOGMI), Università di Genova, 16132 Genova, Italy.ORCID 0000-0001-6823-6069
Francesco FamàDipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-Infantili (DiNOGMI), Università di Genova, 16132 Genova, Italy.
Matteo PardiniDipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-Infantili (DiNOGMI), Università di Genova, 16132 Genova, Italy.
Raffaele FerriOasi Research Institute-IRCCS, 94018 Troina, Italy.ORCID 0000-0001-6937-3065
Filippo CarducciDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-4795-0970
Bartolo LanuzzaOasi Research Institute-IRCCS, 94018 Troina, Italy.
Fabrizio StocchiIRCCS San Raffaele, 00163 Rome, Italy.
Laura VaccaIRCCS San Raffaele, 00163 Rome, Italy.ORCID 0000-0002-6634-4119
Chiara ColettiIRCCS San Raffaele, 00163 Rome, Italy.
Moira MarizzoniBiological Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0003-3749-2988
John Paul TaylorTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4AE, UK.
Lutfu HanoğluDepartment of Neurology, School of Medicine, Istanbul Medipol University, 34810 Istanbul, Turkey.
Nesrin Helvacı YılmazDepartment of Neurology, Medipol University Istanbul Parkinson's Disease and Movement Disorders Center (PARMER), 34718 Istanbul, Turkey.
İlayda KıyıHealth Sciences Institute, Department of Neurosciences, Dokuz Eylül University, 35330 Izmir, Turkey.ORCID 0000-0002-7040-2588
Yağmur Özbek-İşbitirenHealth Sciences Institute, Department of Neurosciences, Dokuz Eylül University, 35330 Izmir, Turkey.ORCID 0000-0001-9152-5707
Anita D'AnselmoDepartment of Aging Medicine and Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-3940-2616
Laura BonanniDepartment of Aging Medicine and Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0001-7443-9233
Roberta BiundoDepartment of General Psychology, University of Padua, 35128 Padova, Italy.
Fabrizia D'AntonioDepartment of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy.
Giuseppe BrunoDepartment of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6948-7169
Angelo AntoniniParkinson and Movement Disorders Unit, Study Center for Neurodegeneration (CESNE), Center for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, University of Padua, 35121 Padua, Italy.ORCID 0000-0003-1040-2807
Franco GiubileiDepartment of Neuroscience, Mental Health, and Sensory Organs, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0002-5495-8949
Lucia FarottiCentre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0003-4389-0798
Lucilla ParnettiDepartment of Medicine and Surgery, University of Perugia, 05100 Perugia, Italy.ORCID 0000-0001-5722-3967
Giovanni B FrisoniLaboratory of Neuroimaging of Aging (LANVIE), University of Geneva, 1205 Geneva, Switzerland.
Claudio BabiloniDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-5245-9839

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) typically show abnormally high delta (<4 Hz) and low alpha (8-12 Hz) rhythms measured from resting-state eyes-closed electroencephalographic (rsEEG) activity. Here, we hypothesized that the abnormalities in rsEEG activity may be greater in ADMCI patients than in those with MCI not due to AD (noADMCI). Furthermore, they may be associated with the diagnostic cerebrospinal fluid (CSF) amyloid-tau biomarkers in ADMCI patients. An international database provided clinical-demographic-rsEEG datasets for cognitively unimpaired older (Healthy; N = 45), ADMCI (N = 70), and noADMCI (N = 45) participants. The rsEEG rhythms spanned individual delta, theta, and alpha frequency bands. The eLORETA freeware estimated cortical rsEEG sources. Posterior rsEEG alpha source activities were reduced in the ADMCI group compared not only to the Healthy group but also to the noADMCI group (

Indexed as

Alpha RhythmAlzheimer Diseasetau ProteinsAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersCognitive DysfunctionElectroencephalographyFemaleHumansMaleMiddle AgedProdromal SymptomsAmyloid beta-PeptidesBiomarkerstau Proteinscerebrospinal fluid (CSF) biomarkersexact low-resolution brain electromagnetic source tomography (eLORETA)mild cognitive impairment due to Alzheimer’s disease (ADMCI)resting-state electroencephalographic (EEG) rhythms

Identifiers

PMID39796211
PMCPMC11720070

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.