Evidence map›Paper›PMID 39796237›Full record

ArticleInternational journal of molecular sciences2025

Chemoprotective Mechanism of Sodium Thiosulfate Against Cisplatin-Induced Nephrotoxicity Is via Renal Hydrogen Sulfide, Arginine/cAMP and NO/cGMP Signaling Pathways.

George J Dugbartey, Karl K Alornyo, Ismaila Adams, Samuel Adjei, Daniel Amoah, Richard Obeng-Kyeremeh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. The Role of Sirt3 in Kidney Health and Disease.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

George J DugbarteyDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Accra P.O. Box LG43, Ghana.
Karl K AlornyoDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Accra P.O. Box LG43, Ghana.
Ismaila AdamsDepartment of Medical Pharmacology, University of Ghana Medical School, Accra P.O. Box KB52, Ghana.ORCID 0000-0001-7113-3888
Samuel AdjeiDepartment of Animal Experimentation, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra P.O. Box LG581, Ghana.ORCID 0000-0001-5954-908X
Daniel AmoahDepartment of Animal Experimentation, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra P.O. Box LG581, Ghana.
Richard Obeng-KyeremehDepartment of Animal Experimentation, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra P.O. Box LG581, Ghana.ORCID 0000-0001-6772-1556

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cisplatin is a common and highly effective chemotherapeutic agent whose nephrotoxic side effect is well-characterized. Sodium thiosulfate (STS), an FDA-approved hydrogen sulfide (H

Indexed as

CisplatinHydrogen SulfideKidneyKidney DiseasesProtective AgentsSignal TransductionThiosulfatesAnimalsAntineoplastic AgentsArginineCyclic AMPCyclic GMPMaleNitric OxideRatsRats, Sprague-DawleyAntineoplastic AgentsArginineCisplatinCyclic AMPCyclic GMPHydrogen SulfideNitric OxideProtective Agentssodium thiosulfateThiosulfatesargininechemoprotectionCisplatin-induced nephrotoxicity (CIN)cyclic adenosine monophosphate (cAMP)cyclic guanosine monophosphate (cGMP)hydrogen sulfide (H2S)nitric oxide (NO)propargylglycine (PAG)sodium thiosulfate (STS)

Identifiers

PMID39796237
PMCPMC11720986

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.