Evidence map›Paper›PMID 39796278›Full record

ArticleInternational journal of molecular sciences2025

Glutaminase-2 Expression Induces Metabolic Changes and Regulates Pyruvate Dehydrogenase Activity in Glioblastoma Cells.

Juan De Los Santos-Jiménez, José A Campos-Sandoval, Tracy Rosales, Bookyung Ko, Francisco J Alonso, Javier Márquez, Ralph J DeBerardinis, José M Matés

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Targeting the Glutaminolysis Pathway in Glaucoma-Associated Fibrosis.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juan De Los Santos-JiménezDepartamento de Biología Molecular y Bioquímica, Universidad de Málaga, 29071 Málaga, Spain.
José A Campos-SandovalDepartamento de Biología Molecular y Bioquímica, Universidad de Málaga, 29071 Málaga, Spain.ORCID 0000-0002-2457-9884
Tracy RosalesChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center (UTSMC), Dallas, TX 75390, USA.
Bookyung KoChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center (UTSMC), Dallas, TX 75390, USA.
Francisco J AlonsoDepartamento de Biología Molecular y Bioquímica, Universidad de Málaga, 29071 Málaga, Spain.ORCID 0000-0002-9431-163X
Javier MárquezDepartamento de Biología Molecular y Bioquímica, Universidad de Málaga, 29071 Málaga, Spain.ORCID 0000-0003-3317-3963
Ralph J DeBerardinisChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center (UTSMC), Dallas, TX 75390, USA.
José M MatésDepartamento de Biología Molecular y Bioquímica, Universidad de Málaga, 29071 Málaga, Spain.ORCID 0000-0001-9795-1993

Funding

Ministerio de Ciencia e Innovación of Spain PID20221403880B-I00
6 · The paper itself

Abstract

Glutaminase controls the first step in glutaminolysis, impacting bioenergetics, biosynthesis and oxidative stress. Two isoenzymes exist in humans, GLS and GLS2. GLS is considered prooncogenic and overexpressed in many tumours, while GLS2 may act as prooncogenic or as a tumour suppressor. Glioblastoma cells usually lack GLS2 while they express high GLS. We investigated how GLS2 expression modifies the metabolism of glioblastoma cells, looking for changes that may explain GLS2's potential tumour suppressive role. We developed LN-229 glioblastoma cells stably expressing GLS2 and performed isotope tracing using U-

Indexed as

Brain NeoplasmsGlioblastomaGlutaminasePyruvate Dehydrogenase ComplexBenzeneacetamidesCell Line, TumorCitric Acid CycleGene Expression Regulation, NeoplasticGlutamineHumansThiadiazolesBenzeneacetamidesCB-839GLS2 protein, humanGLS protein, humanGlutaminaseGlutaminePyruvate Dehydrogenase ComplexThiadiazolescancerglioblastomaglutaminaseglutaminase-2glutaminemetabolomicspyruvate dehydrogenase

Identifiers

PMID39796278
PMCPMC11721818

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.