ArticleNutrients2024
Vitamin D and LC-PUFA and the Presence of Fetal Heart Defects-A Further Part of a Case-Control Study.
Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Maternal Genotype and Dietary Vitamin A Modify Aortic Arch Phenotypes in a Mouse Model of 22q11DS.International journal of molecular sciences · 2025Article
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8 authors.
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Abstract
introductionThe relationship between diet of mothers, including supplementation of vitamin D and Long Chain Polyunsaturated Fatty Acids (LC-PUFA), and the prevalence of congenital heart defects (CHD) in the fetus has not been sufficiently studied. The aim of the study was to investigate the relationship between the intake of vitamin D and LC-PUFA by mother (from diet and with supplementation, including its time of implementation and applied dose), and the risk of CHD in the fetus.
methodsThis was a case-control study with the participation of a total of 79 women with prenatally diagnosed CHD in the fetus and 121 women without CHD in the fetus. The Food Frequency Questionnaire (FFQ) was used with particular emphasis on vitamin D and DHA supplementation. A univariate logistic regression model was used to evaluate the relationship between selected dietary data and the risk of CHD in the fetus.
resultsIn the group of females without CHD in the fetus, the mean values of vitamin D intake, including supplementation, and dietary LC-PUFA + DHA from supplementation, were higher than in women with CHD in the fetus (41.3 ± 24.7 vs. 34.7 ± 27.8 μg;
conclusionsIt seems that increased maternal intake of vitamin D and LC-PUFA, including DHA, through supplementation, may protect fetus against CHD, but the relationship between the occurrence of CHD and diet in this area need further studies.
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