Evidence map›Paper›PMID 39796488›Full record

ArticleNutrients2024

Sex Differences in Gut Microbiota and Their Relation to Arterial Stiffness (MIVAS Study).

Rita Salvado, Cristina Lugones-Sánchez, Sandra Santos-Minguez, Susana González-Sánchez, José A Quesada, Rocío Benito, Emiliano Rodríguez-Sánchez, Manuel A Gómez-Marcos, Pedro Guimarães-Cunha, Jesús M Hernandez-Rivas and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03900338 (Intestinal Microbiota and Its Relationship With Vascular Structure and Function and Cardiovascular Risk, Phase I), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03900338 completednot on this map

Intestinal Microbiota and Its Relationship With Vascular Structure and Function and Cardiovascular Risk, Phase I (MIVAS Study)

TypeobservationalSponsorFundacion para la Investigacion y Formacion en Ciencias de la SaludRan2019 to 2020Enrolled181ConditionsArterial Stiffness, Dysbiosis
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rita SalvadoPrimary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y León Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
Cristina Lugones-SánchezPrimary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y León Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.ORCID 0000-0002-6571-9556
Sandra Santos-MinguezCancer Research Centre, Institute of Molecular and Cellular Biology of Cancer (IBMCC), Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca-CSIC, 37007 Salamanca, Spain.
Susana González-SánchezPrimary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y León Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
José A QuesadaClinical Medicine Department, Miguel Hernandez University, 03550 Alicante, Spain.ORCID 0000-0002-6947-7531
Rocío BenitoCancer Research Centre, Institute of Molecular and Cellular Biology of Cancer (IBMCC), Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca-CSIC, 37007 Salamanca, Spain.ORCID 0000-0001-9781-4198
Emiliano Rodríguez-SánchezPrimary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y León Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.ORCID 0000-0003-3667-7155
Manuel A Gómez-MarcosPrimary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y León Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.ORCID 0000-0003-0133-6123
Pedro Guimarães-CunhaUnidade Local de Saúde do Alto Ave, Center for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk, 4835-044 Guimarâes, Portugal.
Jesús M Hernandez-RivasCancer Research Centre, Institute of Molecular and Cellular Biology of Cancer (IBMCC), Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca-CSIC, 37007 Salamanca, Spain.ORCID 0000-0002-9661-9371
Alex MiraDepartment of Health and Genomics, FISABIO Foundation, 46020 Valencia, Spain.
Luis García-OrtizPrimary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y León Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
Mivas InvestigatorsResearch Network on Chronicity, Primary Care and Health Promotion (RICAPPS), 37005 Salamanca, Spain.

Funding

European Union-Next Generation EU, Facility for Recovery and Resilience (MRR) PI20/00321Government of Castilla y León GRS: 2505/B/22, GRS: 2305/B/21, GRS 2148/B/2020Instituto de Salud Carlos III RD21/0016/0010
6 · The paper itself

Abstract

backgroundRecent research highlights the potential role of sex-specific variations in cardiovascular disease. The gut microbiome has been shown to differ between the sexes in patients with cardiovascular risk factors.

objectivesThe main objective of this study is to analyze the differences between women and men in the relationship between gut microbiota and measures of arterial stiffness.

methodsWe conducted a cross-sectional study in Spain, selecting 180 subjects (122 women, 58 men) aged between 45 and 74. Subjects with arterial stiffness were identified by the presence of at least one of the following: carotid-femoral pulse wave velocity (cf-PWV) above 12 mm/s, cardio-ankle vascular index (CAVI) above nine, or brachial-ankle pulse wave velocity (ba-PWV) above 17.5 m/s. All other cases were considered subjects without arterial stiffness. The composition of the gut microbiome in fecal samples was determined by 16S rRNA sequencing.

resultsWe found that women have a more diverse microbiome than men (Shannon,

conclusionsIn the Spanish population under study, women had higher microbiome diversity and potentially protective genera. The host's gender determines the influence of the same bacteria on arterial stiffness. TRIAL REGISTRATION NUMBER: NCT03900338.

Indexed as

Gastrointestinal MicrobiomeVascular StiffnessAgedCardiovascular DiseasesCross-Sectional StudiesFecesFemaleHumansMaleMiddle AgedPulse Wave AnalysisRNA, Ribosomal, 16SSex FactorsSpainRNA, Ribosomal, 16Scardio–ankle vascular indexgastrointestinal microbiomelarge arteriespulse wave velocitysexshort-chain fatty acidsvascular stiffness

Identifiers

PMID39796488
PMCPMC11723250

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.