Evidence map›Paper›PMID 39796508›Full record

ArticleNutrients2024

Plasma Bacterial Metabolites in Crohn's Disease Pathogenesis and Complications.

Anna Deskur, Filip Ambrożkiewicz, Emilia Samborowska, Wojciech Błogowski, Tadeusz Sulikowski, Andrzej Białek, Iwona Zawada, Krzysztof Dąbkowski, Joanna Mitrus, Jakub Karczmarski and 3 more

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In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna DeskurDepartment of Gastroenterology and Hepatology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
Filip AmbrożkiewiczLaboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, 32300 Pilsen, Czech Republic.ORCID 0000-0001-6850-780X
Emilia SamborowskaMass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland.ORCID 0000-0002-0646-0847
Wojciech BłogowskiInstitute of Medical Sciences, University of Zielona Góra, ul. Zyty 28, 65-046 Zielona Gora, Poland.
Tadeusz SulikowskiDepartment of General, Minimally Invasive, and Gastroenterological Surgery, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
Andrzej BiałekDepartment of Gastroenterology and Hepatology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
Iwona ZawadaDepartment of Gastroenterology and Hepatology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
Krzysztof DąbkowskiDepartment of Gastroenterology and Hepatology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.ORCID 0000-0002-5386-9004
Joanna MitrusInstitute of Biological Sciences, University of Siedlce, Prusa 14, 08-110 Siedlce, Poland.
Jakub KarczmarskiMass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland.ORCID 0000-0002-7976-0365
Patrycja CybulaInstitute of Health Sciences, Faculty of Medical and Health Sciences, University of Siedlce, 08-110 Siedlce, Poland.
Agnieszka PaziewskaInstitute of Health Sciences, Faculty of Medical and Health Sciences, University of Siedlce, 08-110 Siedlce, Poland.
Teresa StarzyńskaDepartment of Gastroenterology and Hepatology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.

Funding

Funding: This work was supported by the Medical Pomeranian University in Szczecin. Funding: This work was supported by the Medical Pomeranian University in Szczecin.
6 · The paper itself

Abstract

BACKGROUND/

objectivesCrohn's disease is known for being associated with an abnormal composition of the bacterial flora, dysbiosis and intestinal function disorders. Metabolites produced by gut microbiota play a pivotal role in the pathogenesis of CD, and the presence of unspecific extraintestinal manifestations.

methodsThe aim of this study was a determination of the level of bacterial metabolites in blood plasma in patients with Crohn's disease. CD patients (29) and healthy individuals (30) were recruited for this study. Bacterial metabolites (SCFAs and TMAO panel) were measured by a liquid chromatography-mass spectrometry system.

resultsA significant correlation (

conclusionsThe analyzed bacterial metabolites of plasma may significantly help in the diagnostic process, and in the monitoring of the disease course and treatment, in a lowly invasive way, as biomarkers after additional research on a larger group of patients.

Indexed as

BacteriaCrohn DiseaseGastrointestinal MicrobiomeAdultBiomarkersCalciumCase-Control StudiesCholineDysbiosisFatty Acids, VolatileFemaleHumansIndicanMaleMethylaminesMiddle AgedBiomarkersCalciumCholineFatty Acids, VolatileIndicanMethylaminestrimethyloxamineCrohn’s diseasegut microbiomeinflammatory bowel diseasesmetabolitesmetabolomeSCFATMAO

Identifiers

PMID39796508
PMCPMC11722665

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.