Evidence map›Paper›PMID 39796516›Full record

ArticleNutrients2024

Folic Acid and Methyltetrahydrofolate Supplementation in the

Karen E Christensen, Marie-Lou Faquette, Daniel Leclerc, Vafa Keser, Yan Luan, Jeanna L Bennett-Firmin, Olga V Malysheva, Alaina M Reagan, Gareth R Howell, Marie A Caudill and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karen E ChristensenDepartments of Human Genetics and Pediatrics, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0003-1741-0375
Marie-Lou FaquetteDepartments of Human Genetics and Pediatrics, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0001-7179-933X
Daniel LeclercDepartments of Human Genetics and Pediatrics, McGill University, Montreal, QC H3A 0C7, Canada.
Vafa KeserDepartments of Human Genetics and Pediatrics, McGill University, Montreal, QC H3A 0C7, Canada.
Yan LuanDepartments of Human Genetics and Pediatrics, McGill University, Montreal, QC H3A 0C7, Canada.
Jeanna L Bennett-FirminCenter of Metabolomics, Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX 75204, USA.
Olga V MalyshevaDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.
Alaina M ReaganThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Gareth R HowellThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Marie A CaudillDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-7192-5743
Teodoro BottiglieriCenter of Metabolomics, Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX 75204, USA.ORCID 0000-0002-4199-7551
Rima RozenDepartments of Human Genetics and Pediatrics, McGill University, Montreal, QC H3A 0C7, Canada.

Funding

CIHR PJT-173521
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe

methodsMale and female C57BL/6J 677CC (CC) and TT mice were fed control (CD), 5xmethylTHF-supplemented (MFSD), or 5xfolic-acid-supplemented (FASD) diets for 4 months. Liver sections were assessed for steatosis by Oil Red O staining. One-carbon metabolites were measured in the liver and plasma. MTHFR protein expression was evaluated in the liver.

resultsMFSD had no significant effect on plasma homocysteine, liver SAM/SAH ratios, or hepatic steatosis in males or females as compared to CD. MTHFR protein increased in MFSD TT female liver, but remained <50% of the CC. FASD had no effect on plasma homocysteine but it decreased the liver MTHFR protein and SAM/SAH ratios, and increased hepatic steatosis in CC females.

conclusionsMethylTHF and folic acid supplementation had limited benefits for TT mice, while folic acid supplementation had negative effects on CC females. Further investigation is required to determine if these effects are relevant in humans.

Indexed as

Dietary SupplementsFatty LiverFolic AcidMethylenetetrahydrofolate Reductase (NADPH2)TetrahydrofolatesAnimalsDisease Models, AnimalFemaleGenotypeHomocysteineLiverMaleMiceMice, Inbred C57BL5-methyltetrahydrofolateFolic AcidHomocysteineMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, mouseTetrahydrofolatesfolic acidhepatic steatosismethyltetrahydrofolatemouse modelMTHFRsupplementation

Identifiers

PMID39796516
PMCPMC11723006

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.