Evidence map›Paper›PMID 39796555›Full record

ArticleNutrients2024

The Unripe Carob Extract (

Laura Micheli, Marilena Muraglia, Filomena Corbo, Daniel Venturi, Maria Lisa Clodoveo, Roberta Tardugno, Valentina Santoro, Anna Lisa Piccinelli, Lorenzo Di Cesare Mannelli, Stefania Nobili and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura MicheliDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, 50139 Florence, Italy.ORCID 0000-0001-8834-5801
Marilena MuragliaDepartment of Pharmacy-Drug Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.ORCID 0000-0001-9185-8405
Filomena CorboDepartment of Pharmacy-Drug Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.ORCID 0000-0002-6951-1103
Daniel VenturiDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, 50139 Florence, Italy.
Maria Lisa ClodoveoInterdisciplinary Department of Medicine, School of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-1717-2197
Roberta TardugnoDepartment of Pharmacy-Drug Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.ORCID 0000-0001-9309-5966
Valentina SantoroDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0003-0859-8230
Anna Lisa PiccinelliDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0001-6102-2762
Lorenzo Di Cesare MannelliDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, 50139 Florence, Italy.ORCID 0000-0001-8374-4432
Stefania NobiliDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, 50139 Florence, Italy.ORCID 0000-0003-4731-9169
Carla GhelardiniDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, 50139 Florence, Italy.

Funding

Italian Ministry of Instruction not applicableNextGenerationEU PE00000003Project funded under the National Recovery and Resilience Plan Mission 4 Component 2 Investment 1.3
6 · The paper itself

Abstract

backgroundOxaliplatin-induced neuropathy (OIN) is a severe painful condition that strongly affects the patient's quality of life and cannot be counteracted by the available drugs or adjuvants. Thus, several efforts are devoted to discovering substances that can revert or reduce OIN, including natural compounds. The carob tree,

methodsBy UHPLC-HRMS/MS analyses, 50 phenolic compounds, belonging mainly to n-galloylated glucoses and flavonoids were detected.

resultsIn a mouse model of oxaliplatin-induced neurotoxicity (2.4 mg/kg, 10 injections over two weeks), acute

conclusionsOverall, our study contributes to the knowledge on up-CS properties by highlighting its protective activity in the painful condition related to the administration of oxaliplatin.

Indexed as

FabaceaeNeuralgiaOxaliplatinPlant ExtractsPlant GumsAnimalsAntineoplastic AgentsAntioxidantsDisease Models, AnimalGalactansMaleMannansMiceAntineoplastic AgentsAntioxidantsGalactanslocust bean gumMannansOxaliplatinPlant ExtractsPlant GumsCeratonia siliqua L.neurotoxicityoxaliplatinpainpolyphenolsunripe carob pods

Identifiers

PMID39796555
PMCPMC11723348

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.