Evidence map›Paper›PMID 39796673›Full record

ReviewCancers2024

Components of the Endosome-Lysosome Vesicular Machinery as Drivers of the Metastatic Cascade in Prostate Cancer.

Bukuru Dieu-Donne Nturubika, Jessica Logan, Ian R D Johnson, Courtney Moore, Ka Lok Li, Jingying Tang, Giang Lam, Emma Parkinson-Lawrence, Desmond B Williams, James Chakiris and 11 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Bukuru Dieu-Donne NturubikaClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0002-3664-9771
Jessica LoganClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0003-4046-6908
Ian R D JohnsonClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0001-7875-3510
Courtney MooreClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0003-3675-4026
Ka Lok LiClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Jingying TangClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Giang LamCentre for Cancer Biology, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0002-2416-1779
Emma Parkinson-LawrenceClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Desmond B WilliamsClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
James ChakirisClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Madison HindesClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0009-0002-8117-5672
Robert D BrooksClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Mark A MilesCentre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia.ORCID 0000-0002-2162-2939
Stavros SelemidisCentre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia.ORCID 0000-0002-3989-7615
Philip GregoryCentre for Cancer Biology, University of South Australia, Adelaide, SA 5000, Australia.
Roberto WeigertLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Lisa ButlerSouth Australian ImmunoGENomics Cancer Institute, Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA 5000, Australia.ORCID 0000-0003-2698-3220
Mark P WardDepartment of Pathology, The Coombe Women and Infants University Hospital, Trinity College Dublin, D08 XW7X Dublin, Ireland.ORCID 0000-0002-9356-7246
David J J WaughCentre for Cancer Biology, University of South Australia, Adelaide, SA 5000, Australia.
John J O'LearyDepartment of Histopathology, Trinity College Dublin, D08 XW7X Dublin, Ireland.ORCID 0000-0001-7311-9326
Douglas A BrooksClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0001-9098-3626

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer remains a significant global health concern, with over 1.4 million new cases diagnosed and more than 330,000 deaths each year. The primary clinical challenge that contributes to poor patient outcomes involves the failure to accurately predict and treat at the onset of metastasis, which remains an incurable stage of the disease. This review discusses the emerging paradigm that prostate cancer metastasis is driven by a dysregulation of critical molecular machinery that regulates endosome-lysosome homeostasis. Endosome and lysosome compartments have crucial roles in maintaining normal cellular function but are also involved in many hallmarks of cancer pathogenesis, including inflammation, immune response, nutrient sensing, metabolism, proliferation, signalling, and migration. Here we discuss new insight into how alterations in the complex network of trafficking machinery, responsible for the microtubule-based transport of endosomes and lysosomes, may be involved in prostate cancer progression. A better understanding of endosome-lysosome dynamics may facilitate the discovery of novel strategies to detect and manage prostate cancer metastasis and improve patient outcomes.

Indexed as

biomarkersendosome-lysosome dynamicsmetastasismolecular motorsprognosisprostate cancerRabsvesicular trafficking machinery

Identifiers

PMID39796673
PMCPMC11718918

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.