Evidence map›Paper›PMID 39797721›Full record

ArticleEpilepsia2025

Progressive central cardiorespiratory rate downregulation and intensifying epilepsy lead to sudden unexpected death in epilepsy in mouse model of the most common human ATP1A3 mutation.

Arsen S Hunanyan, Amitesh Verma, Minu-Tshyeto Bidzimou, Debolina D Biswas, Emily Da Cruz, Meredith K Srour, Joshua Marek, Cordelia Hume, Mai K Elmallah, Andrew P Landstrom and 1 more

Abstract read
In one paragraph

Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arsen S HunanyanDivision of Pediatric Neurology and Developmental Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0001-6052-9035
Amitesh VermaDivision of Pediatric Neurology and Developmental Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA.
Minu-Tshyeto BidzimouDivision of Pediatric Cardiology, Department of Pediatrics, Duke University, Durham, North Carolina, USA.
Debolina D BiswasDivision of Pediatric Pulmonary and Sleep Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA.
Emily Da CruzDivision of Pediatric Neurology and Developmental Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA.
Meredith K SrourDivision of Pediatric Cardiology, Department of Pediatrics, Duke University, Durham, North Carolina, USA.
Joshua MarekDepartment of Neurobiology, Duke University, Durham, North Carolina, USA.
Cordelia HumeDivision of Pediatric Neurology and Developmental Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA.
Mai K ElmallahDivision of Pediatric Pulmonary and Sleep Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA.
Andrew P LandstromDivision of Pediatric Cardiology, Department of Pediatrics, Duke University, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-1878-9631
Mohamad A MikatiDivision of Pediatric Neurology and Developmental Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0003-0363-8715

Funding

Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Exploring the role of ATP1A3 mutations in sudden unexplained death in epilepsyR01HL160654 · NHLBI · DUKE UNIVERSITY · PI Andrew P. Landstrom · 2022 to 2026
$3.4M
Cure AHC donationDuke University 3912274Duke University 3919897NHLBI NIH HHS R01 HL160654NIGMS NIH HHS T32 GM145449NIH HHS 1R01HL160654-01A1
6 · The paper itself

Abstract

objectiveThis study was undertaken to test the following hypotheses in the Atp1a3

methodsComparison was made of littermate wild-type and Atp1a3

resultsIn Atp1a3 SIGNIFICANCE: Atp1a3

Indexed as

EpilepsyHeart RateMutationSodium-Potassium-Exchanging ATPaseSudden Unexpected Death in EpilepsyAnimalsDisease Models, AnimalDown-RegulationElectrocardiographyElectroencephalographyFemaleHumansMaleMiceMice, Inbred C57BLMice, TransgenicAtp1a3 protein, mouseSodium-Potassium-Exchanging ATPaseAHCapneaATP1A3SUDEP

Identifiers

PMID39797721
PMCPMC11908895

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.