Evidence mapPaperPMID 39797725Full record

ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2025

The link of FOXO1 and FOXO4 transcription factors to development of the lens.

Rifah N Gheyas, Ruby C Williams, Kelly A Ryan, A Sue Menko

Abstract read
In one paragraph

Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rifah N GheyasDepartment of Pathology and Genomic Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Ruby C WilliamsDepartment of Pathology and Genomic Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Kelly A RyanDepartment of Pathology and Genomic Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
A Sue MenkoDepartment of Pathology and Genomic Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-7514-4696

Funding

Regulatory role of PI3K signaling pathways in lens differentiation and functionR01EY026478 · THOMAS JEFFERSON UNIVERSITY · 2025 to 2025
$462k
NEI NIH HHS R01 EY026478
6 · The paper itself

Abstract

backgroundThe FOXOs regulate the transcription of many genes, including ones directly linked to pathways required for lens development. However, this transcription factor family has rarely been studied in the context of development, including the development of the lens. FOXO expression, regulation, and function during lens development remained unexplored.

resultsIn studies of the embryonic lens, we showed that both FOXO1 and FOXO4, which share many downstream targets, are expressed in a differentiation-state-specific manner, most highly in lens epithelial and differentiating cortical fiber cells. Their expression patterns and subcellular distributions suggest both shared and distinct functions. Stabilization of FOXO cytoplasmic pools involved their binding to the chaperone protein 14-3-3. FOXO association with β-catenin linked this transcription complex to fiber cell-specific gene activation. Inhibition of PI3K/Akt signaling promoted FOXO1/FOXO4 nuclear localization in lens epithelial and fiber cells and expression of the CDKi p27 in the lens epithelium where it has been linked to lens cell withdrawal from the cell cycle and initiation of the lens differentiation program. We showed that FOXO1 transcriptional activation is required for the induction of p27 when Akt signaling is blocked, demonstrating the linearity of the PI3K/Akt/FOXO1/p27 pathway.

conclusionsPI3K/Akt signaling regulates FOXO-dependent lens cell differentiation.

Indexed as

Forkhead Transcription FactorsLens, CrystallineTranscription FactorsAnimalsCell Cycle ProteinsCell DifferentiationForkhead Box Protein O1Gene Expression Regulation, DevelopmentalMiceProto-Oncogene Proteins c-aktSignal TransductionCell Cycle ProteinsForkhead Box Protein O1Forkhead Transcription FactorsFoxo1 protein, mouseFoxO4 protein, mouseProto-Oncogene Proteins c-aktTranscription FactorsFOXO1FOXO4lens developmentp27PI3K/Akt

Identifiers

PMID39797725
PMCPMC12246175

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.