Evidence map›Paper›PMID 39797759›Full record

ArticleGenes & development2025

E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells.

Alexis U Oguh, Matthew W Haemmerle, Sabyasachi Sen, Andrea V Rozo, Shristi Shrestha, Jean-Philippe Cartailler, Hossein Fazelinia, Hua Ding, Sam Preza, Juxiang Yang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alexis U OguhInstitute for Diabetes, Obesity, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19146, USA.
Matthew W HaemmerleInstitute for Diabetes, Obesity, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19146, USA.
Sabyasachi SenInstitute for Diabetes, Obesity, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19146, USA.
Andrea V RozoInstitute for Diabetes, Obesity, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19146, USA.
Shristi ShresthaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA.
Jean-Philippe CartaillerDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA.
Hossein FazeliniaProteomics Core Facility, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19146, USA.
Hua DingProteomics Core Facility, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19146, USA.
Sam PrezaInstitute for Diabetes, Obesity, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19146, USA.
Juxiang YangInstitute for Diabetes, Obesity, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19146, USA.
Xiaodun YangInstitute for Diabetes, Obesity, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19146, USA.
Lori SusselDepartment of Pediatrics and Cell and Developmental Biology, Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA.ORCID 0000-0003-4672-7304
Juan R Alvarez-DominguezInstitute for Diabetes, Obesity, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19146, USA.
Nicolai DolibaDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19146, USA.
Lynn A SpruceProteomics Core Facility, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19146, USA.
Rafael Arrojo E DrigoDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA.
Doris A StoffersInstitute for Diabetes, Obesity, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19146, USA; stoffers@pennmedicine.upenn.edu.

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI JOSHUA D RABINOWITZ · 1986 to 2026
$48.3M
NIDDK Network Coordinating UnitU24DK097771 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Shuibing Chen, Jeffrey S. Grethe · 2013 to 2026
$20.9M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
Regulation of Pancreatic Islet Cell FateR01DK082590 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2009 to 2026
$7.3M
Functional interaction of transcriptional regulators in endocrine lineage specificationR01DK135032 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Maureen A Gannon, DORIS A STOFFERS · 2023 to 2026
$2.8M
A stress inducible Pdx1 transcriptional complex governing beta cell survivalR01DK121175 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI STOFFERS, DORIS A · 2019 to 2023
$2.3M
Formation and maturation of endocrine pancreas progenitorsR01DK105689 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GANNON, MAUREEN A, STOFFERS, DORIS A · 2016 to 2019
$2.2M
Structure dictates dynamic topology and function of pancreatic transcriptional regulatorsR01DK127270 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Maureen A Gannon, DORIS A STOFFERS · 2024 to 2026
$2.0M
Role of the RNA-binding, polyC-binding proteins in pancreatic beta cellsR01DK122039 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI STOFFERS, DORIS A · 2019 to 2022
$1.8M
Beta cell adaptation mechanisms during caloric restriction and ER stressR01DK138141 · NIDDK · VANDERBILT UNIVERSITY · PI Rafael Arrojo e Drigo · 2024 to 2026
$1.5M
Circadian Control of Pancreatic Beta-cell Maturation by Dec1K01DK129442 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ALVAREZ, JUAN R · 2021 to 2023
$580k
NIDDK NIH HHS K01 DK129442NIDDK NIH HHS P30 DK019525NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK082590NIDDK NIH HHS R01 DK105689NIDDK NIH HHS R01 DK121175NIDDK NIH HHS R01 DK122039NIDDK NIH HHS R01 DK127270NIDDK NIH HHS R01 DK135032NIDDK NIH HHS R01 DK138141NIDDK NIH HHS U24 DK097771
6 · The paper itself

Abstract

The Cullin-3 E3 ligase adaptor protein SPOP targets proteins for ubiquitination and proteasomal degradation. We previously established the β-cell transcription factor (TF) and human diabetes gene PDX1 as an SPOP substrate, suggesting a functional role for SPOP in the β cell. Here, we generated a β-cell-specific

Indexed as

Insulin-Secreting CellsNuclear ProteinsRepressor ProteinsUnfolded Protein ResponseAnimalsEndoplasmic Reticulum StressEndoribonucleasesGlucoseInsulinInsulin SecretionMiceMice, KnockoutProtein Serine-Threonine KinasesSignal TransductionUbiquitin-Protein Ligase ComplexesUbiquitin-Protein LigasesEndoribonucleasesErn1 protein, mouseGlucoseInsulinNuclear ProteinsProtein Serine-Threonine KinasesRepressor ProteinsSpop protein, mouseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein LigasesX-Box Binding Protein 1Xbp1 protein, mousediabetesproteasomeubiquitinunfolded protein responseβ cells

Identifiers

PMID39797759
PMCPMC11789638

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.