Evidence map›Paper›PMID 39797936›Full record

ArticleGeroScience2025

Ethnicity-specific patterns of epigenetic age acceleration in rheumatoid arthritis.

Archana Sharma-Oates, Niall Dunne, Karim Raza, Leonid Padyukov, Natalie Rivera, Annette van der Helm-van Mil, Arthur G Pratt, Niharika A Duggal, Simon W Jones, Janet M Lord

Abstract read
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In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Archana Sharma-OatesSchool of Biosciences, University of Birmingham, Birmingham, UK.
Niall DunneSchool of Biosciences, University of Birmingham, Birmingham, UK.
Karim RazaInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Leonid PadyukovKarolinska Institute, Stockholm, Sweden.
Natalie RiveraKarolinska Institute, Stockholm, Sweden.
Annette van der Helm-van MilUniversity of Leiden, Leiden, the Netherlands.
Arthur G PrattTranslational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.
Niharika A DuggalInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Simon W JonesInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Janet M LordInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK. j.m.lord@bham.ac.uk.ORCID 0000-0003-1030-6786

Funding

Medical Research Council MR/P021220/1
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is an age-related chronic inflammatory disease which may include accelerated biological ageing processes in its pathogenesis. To determine if increased biological age is associated with risk of RA and/or is present once disease is established. We used DNA methylation to compare biological age (epigenetic age) of immune cells in adults at risk of RA and those with confirmed RA, including twins discordant for RA. The established RA studies were secondary analyses of existing DNA methylation data. Sub-group analysis considered the influence of ethnicity. Four epigenetic clocks were used to determine DNA methylation age. DNA methylation age was no different in adults at risk of RA in the Leiden Clinically Suspect Arthralgia (CSA) cohort (n = 38 developed RA, n = 24 did not), and there was also no difference in DNA methylation age between 77 UK twins discordant for RA, or adults with established RA from the Swedish EIRA cohort (n = 342) compared to healthy controls (n = 328). A sub-group analysis of RA patients of South Asian ethnicity (10 RA patients, 14 healthy controls) showed DNA methylation age acceleration of 3.3 years (p = 0.00014) using the mean DNA methylation age of four epigenetic clocks. Our study suggests that epigenetic age acceleration may be differentially influenced by South Asian ethnicity, but that RA was not generally associated with accelerated epigenetic age. The higher epigenetic age in the South Asian patients may explain the earlier age of onset in this minority ethnic population.

Indexed as

AgingArthritis, RheumatoidDNA MethylationEpigenesis, GeneticAdultAgedFemaleHumansMaleMiddle AgedUnited KingdomDNA methylationEpigenetic clockEthnicityRheumatoid arthritisSouth Asian

Identifiers

PMID39797936
PMCPMC12181512

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.