ReviewAmerican journal of cardiovascular drugs : drugs, devices, and other interventions2025
Kidney Injury Following Cardiac Surgery: A Review of Our Current Understanding.
Review in American journal of cardiovascular drugs : drugs, devices, and other interventions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence and risk factors of acute kidney injury following Stanford type A aortic dissection surgery: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Association between preoperative hydration and cardiac surgery-associated acute kidney injury: a prospective observational study.Journal of cardiothoracic surgery · 2026Observational
- Increased Retinol Levels in Patients with Cardiac Surgery-Associated Acute Kidney Injury-A Prospective Single-Center Exploratory Study.Nutrients · 2026Article
- Rethinking flow: the paradox of renoprotection without increased renal blood flow in cardiopulmonary bypass.Journal of thoracic disease · 2026Article
- Immediate postoperative urine dipstick occult blood positivity: a simple and early indicator of high-risk acute kidney injury after on-pump cardiac surgery.BMC nephrology · 2026Article
- Plasma from Cardiac Surgery Patients Induces Endothelial and Tubular Epithelial Cell Damage: Potential Role in Acute Kidney Injury Development-A Preliminary Report.International journal of molecular sciences · 2026Article
- Amino acid infusion and renal protection in chronic kidney disease patients undergoing cardiac surgery: physiology meets clinical evidence.Journal of thoracic disease · 2026Article
- Cardiac surgery-associated acute kidney injury.BJA education · 2026Review
- Impact of occult renal dysfunction on postoperative acute kidney injury and late prognosis in elderly patients undergoing coronary artery bypass.BMC nephrology · 2026Observational
- Trauma Preconditioning of Cytokine Response: Comparison of Perioperative Cytokine Profiles in Elective Cardiac versus Orthopaedic Trauma Surgery Patients.International journal of nephrology and renovascular disease · 2026Article
- New Insights in Assessing AKI 3 Risk Factors and Predictors Associated with On-Pump Surgical Aortic Valve Replacement.Diagnostics (Basel, Switzerland) · 2025Article
- Predictability of kinetic estimated glomerular filtration rate for acute kidney injury in patients undergoing coronary artery bypass surgery.BMC nephrology · 2025Article
- Is High-Dose Ubiquinone Therapy Before Cardiac Surgery Enough to Reduce the Incidence of Cardiac Surgery-Associated Acute Kidney Injury? A Randomized Controlled Trial.Antioxidants (Basel, Switzerland) · 2025Article
- Preexisting statin therapy is not associated with reduced acute kidney injury following cardiac surgery: a retrospective analysis.Frontiers in pharmacology · 2025Review
- Risk factors for postoperative acute kidney injury after cardiac surgery.Archivos peruanos de cardiologia y cirugia cardiovascularArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Around one-quarter of all patients undergoing cardiac procedures, particularly those on cardiopulmonary bypass, develop cardiac surgery-associated acute kidney injury (CSA-AKI). This complication increases the risk of several serious morbidities and of mortality, representing a significant burden for both patients and the healthcare system. Patients with diminished kidney function before surgery, such as those with chronic kidney disease, are at heightened risk of developing CSA-AKI and have poorer outcomes than patients without preexisting kidney injury who develop CSA-AKI. Several mechanisms are involved in the development of CSA-AKI; injury is primarily thought to result from an amplification loop of inflammation and cell death, with complement and immune system activation, cardiopulmonary bypass, and ischemia-reperfusion injury all contributing to pathogenesis. At present there are no effective, targeted pharmacological therapies for the prevention or treatment of CSA-AKI, although several preclinical trials have shown promise, and clinical trials are under way. Progress in the understanding of the complex pathophysiology of CSA-AKI is needed to improve the development of successful strategies for its prevention, management, and treatment. In this review, we outline our current understanding of CSA-AKI development and management strategies and discuss potential future therapeutic targets under investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.