ArticleJournal of biomedical science2025
N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis.
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Article in Journal of biomedical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Histone chaperone HIRA restrains ferroptosis susceptibility through epigenetic control of iron metabolism in prostate cancer.Science China. Life sciences · 2026Article
- RNA modifications as determinants of cancer cell death: from epitranscriptomic mechanisms to therapeutic targeting.Functional & integrative genomics · 2026Review
- Targeting taurine metabolism via PROTAC-mediated SLC6A6 degradation potentiates photodynamic therapy and reverses immunosuppression in cholangiocarcinoma.Journal of nanobiotechnology · 2026Article
- Decoding the spatiotemporal characteristics of ferroptosis: reshaping tumour therapeutic strategies.Experimental hematology & oncology · 2026Review
- Regulation of mCell biology and toxicology · 2026Review
- Mechanism and therapeutic prospects of ferroptosis regulation through m6A in cancer.Frontiers in cell and developmental biology · 2026Review
- Ferroptosis in Müller cells under hyperglycemia: mechanisms and therapeutic implications for diabetic retinopathy-associated optic neuroinflammation.International ophthalmology · 2025Review
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Authors and funding
16 authors.
Haisheng Zhang *Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Cheng Yi *Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Jianing LiGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Yunqing LuGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Haoran WangGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Lijun TaoGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Jiawang ZhouGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Yonghuang TanGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Jiexin LiGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Zhuojia ChenState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Gholamreza AsadikaramEndocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Medical University Campus, Kerman, Iran.
Jie CaoDepartment of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, 510180, China.
Jianxin PengDepartment of Hepatobiliary Surgery, Guangdong Province Traditional Chinese Medical Hospital, Guangzhou, 510120, China.
Wanglin LiDepartment of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, 510180, China. eylwl@scut.edu.cn.
Junming HeDepartment of Hepatobiliary Surgery, Guangdong Province Traditional Chinese Medical Hospital, Guangzhou, 510120, China. hejunming0101@sina.com.
Hongsheng WangGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. whongsh@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-0054-4820
Funding
Fundamental Research Funds for the Central Universities (Sun Yat-sen University) -Young Faculty Cultivation Project 23qnpy117Guangdong Basic and Applied Basic Research Foundation 2021A1515111161Guangdong Basic and Applied Basic Research Foundation 2023A1515010118Guangdong Basic and Applied Basic Research Foundation 2023B1515040006Guangdong Provincial Key Laboratory of Construction Foundation 2023B1212060022Key-Area Research and Development Program of Guangdong Province 2023B1111020007National Key Research and Development Program of China No. 2022YFC2601800National Natural Science Foundation of China 32161143017National Natural Science Foundation of China 82173126National Natural Science Foundation of China 82173833National Natural Science Foundation of China 82341053National Natural Science Foundation of China 82372743National Natural Science Foundation of China 82373893Open Program of Shenzhen Bay Laboratory SZBL202009051006
Abstract
backgroundRecent studies indicate that N6-methyladenosine (m
methodsLiquid Chromatography-Tandem Mass Spectrometry (HPLC/MS/MS) was used to detect changes in m
resultsThe m
conclusionsMETTL3 regulated the transcription of SLC7A11 through GATA3 and KDM6B to modulate ferroptosis in an m
Indexed as
AdenosineAmino Acid Transport System y+FerroptosisGATA3 Transcription FactorJumonji Domain-Containing Histone DemethylasesMethyltransferasesAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMiceAdenosineAmino Acid Transport System y+GATA3 protein, humanGATA3 Transcription FactorJumonji Domain-Containing Histone DemethylasesKDM6B protein, humanMethyltransferasesMETTL3 protein, humanN-methyladenosineSLC7A11 protein, humanFerroptosisGATA3KDM6BMETTL3SLC7A11
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.