Evidence map›Paper›PMID 39801737›Full record

ArticleImmune network2024

Sphingosylphosphorylcholine Promotes Th9 Cell Differentiation Through Regulation of Smad3, STAT5, and β-Catenin Pathways.

Ji Cheol Kim, Wonseok Hu, Mingyu Lee, Geon Ho Bae, Ji Ye Park, Suh Yeon Lee, Yu Sun Jeong, Byunghyun Park, Joon Seong Park, Brian A Zabel and 2 more

Abstract read
In one paragraph

Article in Immune network, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ji Cheol KimDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea.
Wonseok HuDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea.
Mingyu LeeDepartment of Health Science and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Korea.
Geon Ho BaeDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea.ORCID https://orcid.org/0000-0002-8875-9761
Ji Ye ParkDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea.
Suh Yeon LeeDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea.
Yu Sun JeongDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea.ORCID https://orcid.org/0009-0009-1438-2840
Byunghyun ParkDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea.
Joon Seong ParkDepartment of Hematology-Oncology, Ajou University School of Medicine, Suwon 16499, Korea.ORCID https://orcid.org/0009-0008-4289-3907
Brian A ZabelPalo Alto Veterans Institute for Research (PAVIR), VA Palo Alto Health Care Systems (VAPAHCS), Palo Alto, CA 94304, USA.ORCID https://orcid.org/0000-0001-7293-6180
Yong-Soo BaeDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea.ORCID https://orcid.org/0000-0002-2233-9449
Yoe-Sik BaeDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, Korea.ORCID https://orcid.org/0000-0002-6198-4512

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sphingosylphosphorylcholine (SPC) is one of sphingomyelin-derived sphingolipids. SPC levels are increased in ascitic fluids of ovarian cancer patients and stratum corneum of atopic dermatitis (AD) patients. SPC has antitumor activity against several cancer cells by reducing proliferation and migration and increasing apoptosis

Indexed as

Beta-cateninInterleukin-9Reactive oxygen speciesSmad3 proteinSphingosylphosphorylcholineSTAT5 transcription factor

Identifiers

PMID39801737
PMCPMC11711130

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.