Evidence map›Paper›PMID 39801741›Full record

ArticleImmune network2024

Activation of Immune Responses Through the RIG-I Pathway Using TRITC-Dextran Encapsulated Nanoparticles.

Hayeon Baek, Seung-Woo Yang, Min-Kyung Kim, Dongwoo Kim, Chaeyeon Lee, Seulki Kim, Yunseok Lee, Min Park, Han-Sung Hwang, Hyun-Jong Paik and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immune network, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hayeon BaekDepartment of KONKUK-KIST Biomedical Science & Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0009-0006-8266-0046
Seung-Woo YangSanford Consortium for Regenerative Medicine, School of Medicine, University of California, San Diego, CA 92521, USA.ORCID https://orcid.org/0000-0001-8727-7528
Min-Kyung KimDepartment of KONKUK-KIST Biomedical Science & Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0009-0009-5897-0353
Dongwoo KimDepartment of Polymer Science and Engineering, Pusan National University, Busan 46241, Korea.ORCID https://orcid.org/0009-0007-7115-9093
Chaeyeon LeeDepartment of Polymer Science and Engineering, Pusan National University, Busan 46241, Korea.ORCID https://orcid.org/0009-0002-8685-0251
Seulki KimDepartment of Veterinary Pharmacology and Toxicology, Veterinary Science Research Institute, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0009-0005-2791-1888
Yunseok LeeDepartment of Animal Science and Technology, College of Sang-Huh Life Science, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0009-0002-2958-2182
Min ParkDepartment of KONKUK-KIST Biomedical Science & Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0003-2265-3451
Han-Sung HwangDivision of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul 05029, Korea.ORCID https://orcid.org/0000-0003-0622-0701
Hyun-Jong PaikDepartment of Polymer Science and Engineering, Pusan National University, Busan 46241, Korea.ORCID https://orcid.org/0000-0002-0821-9096
Young-Sun KangDepartment of KONKUK-KIST Biomedical Science & Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0002-3527-9879

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogen-associated molecular patterns (PAMPs) are highly conserved motifs originating from microorganisms that act as ligands for pattern recognition receptors (PRRs), which are crucial for defense against pathogens. Thus, PAMP-mimicking vaccines may induce potent immune activation and provide broad-spectrum protection against microbes. Dextran encapsulation can regulate the surface characteristics of nanoparticles (NPs) and induces their surface modification. To determine whether dextran-encapsulated NPs can be used to develop antiviral vaccines by mimicking viral PAMPs, we synthesized NPs in a cyclohexane inverse miniemulsion (Basic-NPs) and further encapsulated them with dextran or tetramethylrhodamine isothiocyanate (TRITC)-dextran (Dex-NPs or TDex-NPs). We hypothesized that these dextran encapsulated NPs could activate innate immunity through cell surface or cytosolic PRRs.

Indexed as

Interferon-alphaNanoparticlesPathogen-associated molecular patternPathogen-associated molecular pattern moleculesReceptors, pattern recognitionRetinoic acid-inducible gene I

Identifiers

PMID39801741
PMCPMC11711124

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.