ArticleHeliyon2025
Exploring the link between exposure to volatile organic chemicals and incidence of infertility:A cross-sectional study.
Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- A Study on the Mechanism of Acetyl Tributyl Citrate-Induced Infertility Toxicity and the Protective Action of Icariin Based on Network Toxicology, Network Pharmacology, Molecular-Docking Technology and Molecular Dynamics Simulation.International journal of molecular sciences · 2026Article
- Exploring the nexus between particulate matter and infertility: Multiple mechanistic insights and potential control strategies.iScience · 2026Review
- Machine learning prediction of osteoarthritis risk from volatile organic compound exposure using SHAP interpretation in US adults.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Growing evidence suggests that environmental pollutants exert a detrimental impact on female fertility. Among these pollutants, volatile organic compounds (VOCs), easily encountered in the environment, have garnered significant attention as prevalent airborne contaminants. Nevertheless, a definitive consensus regarding the association between VOCs and the incidence of infertility remains elusive. Method: Conducted as a cross-sectional study, this research utilized data from three survey cycles of the NHANES program spanning from 2013 to 2018. The objective was to delve into the relationship between volatile organic compounds and the prevalence of infertility. The definition of infertility relied upon information derived from the reproductive health questionnaire. In order to comprehensively explore this relationship, various analytical models, including logistic regression, weighted quantile sum (WQS), and Bayesian kernel-machine regression (BKMR), were employed. Result: A total of 1098 participants, 120 in the infertility group and 978 in the control group, were included. All 15 volatile organic compounds showed higher concentrations in the infertility group's urine. Multivariate regression revealed that the highest AMCC (N-acetyl-S-(N-methylcarbamoyl)-L-cysteine) and CYMA (2-hydroxyethyl mercapturic acid) quartiles associated with significant infertility increases, approximately 191 % and 128 %, respectively, versus the lowest quartile (OR for AMCC = 2.91; 95%CI: 1.33, 6.37; OR for CYMA = 2.28; 95%CI: 1.01, 5.15). This emphasizes AMCC and CYMA's role in infertility, supported by WQS and BKMR studies. Inflammation mediates AMCC's impact on infertility, enhancing our understanding of volatile organic compounds and reproductive health. Conclusion: The study highlights the correlation between VOCs exposure, notably AMCC and CYMA, and infertility. It identifies inflammation as a mediating factor connecting AMCC to infertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.