Evidence map›Paper›PMID 39802799›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Causal mediation analysis of the neuroprotection of

Qingyan Xiang, Judith J Lok, Nicole Roth, Stacy L Andersen, Thomas T Perls, Zeyuan Song, Anatoli I Yashin, Jonas Mengel-From, Gary J Patti, Paola Sebastiani

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qingyan XiangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States.ORCID 0000-0003-4717-3809
Judith J LokDepartment of Mathematics and Statistics, Boston University, Boston, MA, United States.
Nicole RothSection of Geriatrics, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States.
Stacy L AndersenSection of Geriatrics, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States.
Thomas T PerlsSection of Geriatrics, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States.
Zeyuan SongInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, United States.
Anatoli I YashinBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, United States.
Jonas Mengel-FromDepartment of Public Health, University of Southern Denmark, Denmark.
Gary J PattiDepartment of Genetics, Washington University in St. Louis, St. Louis, MO, United States.
Paola SebastianiInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, United States.

Funding

The Long Life Family StudyU19AG063893 · NIA · WASHINGTON UNIVERSITY · PI PAOLA SEBASTIANI · 2019 to 2026
$125.4M
Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI PAOLA SEBASTIANI · 2004 to 2026
$102.6M
Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategiesUH3AG064704 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI PERLS, THOMAS T, SEBASTIANI, PAOLA · 2022 to 2025
$14.7M
Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategiesUH2AG064704 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI PERLS, THOMAS T, SEBASTIANI, PAOLA · 2019 to 2021
$9.4M
Integrative Omics to enhance therapeutics development for healthy agingUH3AG064706 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI MILLER, RICHARD A, SCHORK, NICHOLAS JOSEPH · 2021 to 2024
$3.3M
Protein Signatures of APOE2 and Cognitive AgingR01AG061844 · NIA · TUFTS MEDICAL CENTER · PI PERLS, THOMAS T, SEBASTIANI, PAOLA · 2018 to 2022
$3.1M
NIA NIH HHS R01 AG061844NIA NIH HHS U19 AG023122NIA NIH HHS U19 AG063893NIA NIH HHS UH2 AG064704NIA NIH HHS UH3 AG064704NIA NIH HHS UH3 AG064706
6 · The paper itself

Abstract

Background: Recent studies have revealed a strong association between the e2 allele of the Apolipoprotein E ( Methods: We conducted a causal mediation analysis to estimate both the direct effect of Results: Compared to carriers of the common Conclusions: We found that the combined indirect effect through all lipids could mediate 10%-27% of the total direct effect of

Indexed as

Apolipoprotein ECognitionDigital AssessmentLongevityMediation analysis

Identifiers

PMID39802799
PMCPMC11722459

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.