ArticleInternational journal of clinical and experimental pathology2024
Bmi-1 plays an important role in preventing bone aging by regulating the bone microenvironment.
Article in International journal of clinical and experimental pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- LncRNA CRNDE regulates the differentiation of tendon-derived stem cells and enhances rotator cuff injury repair by modulating the miR-337/TGFBR2 axis.International journal of clinical and experimental pathology · 2025Article
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Abstract
backgroundB-cell specific Moloney MLV insertion site-1 (Bmi-1) belongs to the polycomb group (PcG) gene and is a transcriptional suppressor to maintain appropriate gene expression patterns during development. To investigate whether the Bmi-1 gene has a corrective effect on bone senescence induced in Bmi-1
methodsLittermate heterozygous male and female mice (Bmi-1
resultsOur results indicated that the Bmi-1 gene could proportionally rescued mice suffering from bone aging induced by Bmi-1 gene defects. Bmi-1 plays an anti-aging effect in bone through multiple aspects, such as increasing osteoblast bone formation and decreascing osteoclast bone absorption, stimulating proliferation, reducing apoptosis, inhibiting reactive oxygen species (ROS) and delaying DNA damage.
conclusionsOur results suggested that Bmi-1 may play a fundamental and important role in correcting bone senescence in BKO mice. At the same time, it may provide theoretical basis for the clinical application of Bmi-1 in anti-aging in bone.
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