Evidence map›Paper›PMID 39803443›Full record

ArticlebioRxiv : the preprint server for biology2024

Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection.

Dipanwita Mitra, Darby Oldenburg, J Craig Forrest, Laurie T Krug

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Dipanwita MitraHIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD, USA.
Darby OldenburgGundersen Medical Foundation: Virology Research, La Crosse, WI, USA.
J Craig ForrestDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Laurie T KrugHIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-9648-522X

Funding

Gammaherpesvirus interactions with host tumor suppressor p53R01CA167065 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI James Craig Forrest · 2014 to 2026
$3.8M
Novel interventions for gammaherpesvirus infection and AIDS-Related MalignanciesZIABC012014 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KRUG, LAURIE TATE · 2020 to 2025
$2.7M
Defining KSHV LANA functions in viral pathogenesis and immune evasionR01AI181787 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI James Craig Forrest · 2024 to 2026
$1.4M
Intramural NIH HHS ZIA BC012014NCI NIH HHS R01 CA167065NIAID NIH HHS R01 AI181787
6 · The paper itself

Abstract

Gammaherpesviruses are oncogenic pathogens that establish lifelong infections. There are no FDA-approved vaccines against Epstein-Barr virus or Kaposi sarcoma herpesvirus. Murine gammaherpesvirus-68 (MHV68) infection of mice provides a system for investigating of gammaherpesvirus pathogenesis and testing vaccine strategies. Prime-boost vaccination with a replication-dead virus (RDV) that does not express the essential replication and transactivator protein (RTA) encoded by

Indexed as

gammaherpesviruslatency establishmentMHV68reactivationreplication-dead virusvaccine

Identifiers

PMID39803443
PMCPMC11722263

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.