Evidence map›Paper›PMID 39803456›Full record

ArticlebioRxiv : the preprint server for biology2025

Nde1 Promotes Lis1 Binding to Full-Length Autoinhibited Human Dynein-1.

Jun Yang, Yuanchang Zhao, Pengxin Chai, Ahmet Yildiz, Kai Zhang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jun YangDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA.
Yuanchang ZhaoPhysics Department, University of California, Berkeley, CA 94709, USA.
Pengxin ChaiDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA.
Ahmet YildizPhysics Department, University of California, Berkeley, CA 94709, USA.
Kai ZhangDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA.

Funding

Project 3. IntegrationU54AI170791 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANGELA M. GRONENBORN · 2022 to 2026
$30.6M
The Mechanism and Regulation of the Dynein Transport MachineryR35GM136414 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Ahmet Yildiz · 2020 to 2026
$5.1M
Structural basis of dynein-driven ciliary motilityR35GM142959 · NIGMS · YALE UNIVERSITY · PI ZHANG, KAI JACK · 2021 to 2025
$2.3M
High-throughput electron cryo-microscopeS10OD023603 · OD · YALE UNIVERSITY · PI SIGWORTH, FREDERICK J · 2018 to 2018
$1.9M
NIAID NIH HHS U54 AI170791NIGMS NIH HHS R35 GM136414NIGMS NIH HHS R35 GM142959NIH HHS S10 OD023603
6 · The paper itself

Abstract

Cytoplasmic dynein-1 (dynein) is the primary motor for the retrograde transport of intracellular cargoes along microtubules. The activation of the dynein transport machinery requires the opening of its autoinhibited Phi conformation by Lis1 and Nde1/Ndel1, but the underlying mechanism remains unclear. Using biochemical reconstitution and cryo-electron microscopy, we show that Nde1 significantly enhances Lis1 binding to autoinhibited dynein and facilitates the opening of Phi. We discover a key intermediate step in the dynein activation pathway where a single Lis1 dimer binds between the Phi-like (Phi

Identifiers

PMID39803456
PMCPMC11722290

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.