Evidence map›Paper›PMID 39803463›Full record

ArticlebioRxiv : the preprint server for biology2025

Tissue-Specific Ablation of Liver Fatty Acid-Binding Protein Induces a Metabolically Healthy Obese Phenotype in Female Mice.

Hiba Radhwan Tawfeeq, Atreju I Lackey, Yinxiu Zhou, Anastasia Diolointzi, Sophia Zacharisen, Yin Hei Lau, Loredana Quadro, Judith Storch

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Hiba Radhwan TawfeeqDepartment of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey.
Atreju I LackeyDepartment of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey.
Yinxiu ZhouDepartment of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey.
Anastasia DiolointziDepartment of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey.
Sophia ZacharisenDepartment of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey.
Yin Hei LauDepartment of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey.
Loredana QuadroRutgers Center for Lipid Research, New Brunswick, New Jersey.
Judith StorchDepartment of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey.ORCID 0000-0001-5482-1777

Funding

Supplement to DK-38389 Lipid Transport in the IntestineR01DK038389 · NIDDK · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI SAMPATH, HARINI, STORCH, JUDITH · 1992 to 2025
$8.6M
NIDDK NIH HHS R01 DK038389
6 · The paper itself

Abstract

Background/Objectives: Obesity is associated with numerous metabolic complications including insulin resistance, dyslipidemia, and a reduced capacity for physical activity. Whole-body ablation of liver fatty acid-binding protein (LFABP) in mice was shown to alleviate several of these metabolic complications; high fat (HF) fed LFABP knockout (LFABP Methods: Female liver-specific LFABP knockout (LFABP Results: While not as dramatic as found for whole-body LFABP Conclusions: The results suggest, therefore, that either liver-specific or intestine-specific ablation of LFABP in female mice is sufficient to induce, at least in part, the MHO phenotype observed following whole-body ablation of LFABP.

Indexed as

high-fat dietliverLiver fatty acid-binding proteinmetabolically healthy obesemousesmall intestine

Identifiers

PMID39803463
PMCPMC11722216

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.