Evidence map›Paper›PMID 39803515›Full record

ArticlebioRxiv : the preprint server for biology2024

Neurodegenerative and neurodevelopmental roles for bulk lipid transporters

Sarah D Neuman, Rajan S Thakur, Scott J Gratz, Kate M O'Connor-Giles, Arash Bashirullah

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Funding

Molecular mechanisms of synapse assembly and functionR01NS078179 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR-GILES, KATHALEEN M · 2013 to 2023
$3.6M
Analysis of Bulk Lipid Transport at Membrane Contact SitesR01GM155154 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ARASH BASHIRULLAH, TIMOTHY S BUGNI · 2024 to 2026
$1.5M
NIGMS NIH HHS R01 GM155154NINDS NIH HHS R01 NS078179
6 · The paper itself

Abstract

Background: Bridge-like lipid transfer proteins (BLTPs) mediate bulk lipid transport at membrane contact sites. Mutations in BLTPs are linked to both early-onset neurodevelopmental and later-onset neurodegenerative diseases, including movement disorders. The tissue specificity and temporal requirements of BLTPs in disease pathogenesis remain poorly understood. Objectives: To determine the age-of-onset and tissue-specific roles of Methods: We generated tissue-specific knockdowns of the Results: Neuron-specific loss of the Conclusions:

Identifiers

PMID39803515
PMCPMC11722402

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.