Evidence map›Paper›PMID 39803555›Full record

ArticlebioRxiv : the preprint server for biology2025

Non-nucleosomal (CENP-A/H4)

Ahmad Ali-Ahmad, Mira Mors, Manuel Carrer, Xinmeng Li, Silvija Bilokapić, Mario Halić, Michele Cascella, Nikolina Sekulić

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmad Ali-AhmadCentre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, Faculty of Medicine, University of Oslo, Oslo 0318, Norway.
Mira MorsDepartment of Chemistry, University of Oslo, P.O. Box 1033, Blindern 0315, Norway.
Manuel CarrerDepartment of Chemistry, University of Oslo, P.O. Box 1033, Blindern 0315, Norway.
Xinmeng LiDepartment of Chemistry, University of Oslo, P.O. Box 1033, Blindern 0315, Norway.
Silvija BilokapićDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mario HalićDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Michele CascellaDepartment of Chemistry, University of Oslo, P.O. Box 1033, Blindern 0315, Norway.
Nikolina SekulićCentre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, Faculty of Medicine, University of Oslo, Oslo 0318, Norway.ORCID 0000-0001-7555-3222

Funding

Structural and functional studies of chromatin modifiersR01GM135599 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HALIC, MARIO · 2020 to 2023
$1.5M
Chromatin of repetitive elementsR01GM141694 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HALIC, MARIO · 2021 to 2024
$1.4M
NIGMS NIH HHS R01 GM135599NIGMS NIH HHS R01 GM141694
6 · The paper itself

Abstract

The centromere is a part of the chromosome that is essential for the even segregation of duplicated chromosomes during cell division. It is epigenetically defined by the presence of the histone H3 variant CENP-A. CENP-A associates specifically with a group of 16 proteins that form the centromere-associated network of proteins (CCAN). In mitosis, the kinetochore forms on the CCAN to connect the duplicated chromosomes to the microtubules protruding from the cell poles. Previous studies have shown that CENP-A replaces H3 in nucleosomes, and recently the structures of CENP-A-containing nucleosomes in complex with CCANs have been revealed, but they show only a limited interaction between CCANs and CENP-A. Here, we report the cryoEM structure of 2x(CENP-A/H4)

Identifiers

PMID39803555
PMCPMC11722257

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.