Evidence map›Paper›PMID 39803754›Full record

ArticleCNS neuroscience & therapeutics2025

The Efficacy of Intensive Statin Therapy in Acute Ischemic Stroke Following Intravenous Thrombolysis: The CASE II Study.

Fujian Chen, Huan Zhou, Tingxia Zhang, Liangxue Wang, Hongfang Chen, Jin Hu, Guomin Xie, Shenqiang Yan, Min Lou, CASE‐II Investigators

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fujian ChenDepartment of Neurology, People's Hospital of Anji, Huzhou, China.
Huan ZhouDepartment of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Tingxia ZhangDepartment of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Liangxue WangDepartment of Neurology, People's Hospital of Anji, Huzhou, China.
Hongfang ChenDepartment of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Jin HuDepartment of Neurology, The First Affiliated Hospital of Jiaxing University, Jiaxing, China.
Guomin XieDepartment of Neurology, Ningbo Medical Center Li Huili Hospital, Ningbo, China.
Shenqiang YanDepartment of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Min LouDepartment of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
CASE‐II Investigators

Funding

National Natural Science Foundation of China 82171276
6 · The paper itself

Abstract

aimsThis study aimed to investigate the efficacy of early intensive statin therapy following intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS).

methodsAIS patients who received IVT and statin therapy were included from multicenter registry databases. The primary endpoint was functional independence, defined by a modified Rankin Scale (mRS) score of 0-2 at 90 days. Propensity score matching (PSM) analyses were employed.

resultsA total of 21,349 patients were included in this study, with a mean age of 68.5 ± 12.6 years, of whom 13,578 (63.6%) were male. The baseline NIHSS score was 4 (IQR 2-8). A total of 9532 patients (44.6%) received intensive statin therapy. In the PSM analysis, the proportion of patients with mRS scores of 0-2 was significantly higher in the intensive statin therapy group (OR = 1.095, 95% CI 1.022-1.173, p = 0.010). Statin type modified the effect of intensive statin therapy on functional independence (p-value for interaction = 0.030). Treatment effects favoring the intensive approach were observed in patients receiving atorvastatin (OR = 1.134, 95% CI 1.051-1.224, p = 0.001).

conclusionEarly intensive statin therapy following IVT leads to a significant but modest improvement in neurological outcomes, particularly in patients treated with atorvastatin as part of the intensive regimen.

Indexed as

Brain IschemiaFibrinolytic AgentsHydroxymethylglutaryl-CoA Reductase InhibitorsIschemic StrokeThrombolytic TherapyAdministration, IntravenousAgedAged, 80 and overFemaleHumansMaleMiddle AgedRegistriesTreatment OutcomeFibrinolytic AgentsHydroxymethylglutaryl-CoA Reductase Inhibitorsischemic strokelow‐density lipoproteinreal‐world studystatinthrombolysis

Identifiers

PMID39803754
PMCPMC11726118

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.