Evidence map›Paper›PMID 39804492›Full record

ArticleArchives of dermatological research2025

Ameliorative effects of squid phospholipids from Todarodes pacificus on atopic dermatitis-like lesions in NC/Nga mice.

Akira Sato, Genta Sato, Ayano Yabuki, Yuta Ogawa, Hina Nemoto, Makoto Ohira

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Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Akira SatoDepartment of Food and Nutritional Science, Faculty of Human Life Science, Miyagi Gakuin Women's University, 9-1-1, Sakuragaoka, Aoba-ku, Sendai, Miyagi, 981-8557, Japan. a.sato@mgu.ac.jp.
Genta SatoFaculty of Pharmacy, Iryo Sosei University, 5-5-1, Chuodai-Iino, Iwaki, Fukushima, 970-8551, Japan.
Ayano YabukiFaculty of Pharmacy, Iryo Sosei University, 5-5-1, Chuodai-Iino, Iwaki, Fukushima, 970-8551, Japan.
Yuta OgawaFaculty of Pharmacy, Iryo Sosei University, 5-5-1, Chuodai-Iino, Iwaki, Fukushima, 970-8551, Japan.
Hina NemotoFaculty of Pharmacy, Iryo Sosei University, 5-5-1, Chuodai-Iino, Iwaki, Fukushima, 970-8551, Japan.
Makoto OhiraFaculty of Pharmacy, Iryo Sosei University, 5-5-1, Chuodai-Iino, Iwaki, Fukushima, 970-8551, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis (AD), also known as eczema, is a chronic or relapsing inflammatory skin disease characterized by repeated exacerbations and remissions. Here, we investigated the effects of squid phospholipids (PLs) extracted from Todarodes pacificus on AD. The composition of squid PLs was analyzed using thin-layer chromatography and high-performance liquid chromatography, and the effects of PLs on AD were investigated using a rat paw edema model and an AD-like mouse model (NC/Nga mice). Squid PLs mainly consist of phosphatidylethanolamine (PE), phosphatidylcholine (PC), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid, which are bound at the sn-2 positions of PE and PC. Squid PLs inhibited rat paw edema induced by platelet-activating factor, a highly potent pro-inflammatory mediator. In an AD mouse model (NC/Nga mice), the topical application of squid PLs (1% or 5%) improved dermatitis of the ears and reduced thickness of the ears and epidermis in dermatitis, but 1.2% DHA or 1% soybean PC did not affect them. There results suggest that squid PLs, which mainly consist of PC and PE, and contain DHA, EPA, and ARA at the sn-2 position, may be useful for the prevention and treatment of AD.

Indexed as

DecapodiformesDermatitis, AtopicPhospholipidsAnimalsArachidonic AcidDisease Models, AnimalDocosahexaenoic AcidsEdemaEicosapentaenoic AcidMaleMicePhosphatidylcholinesPhosphatidylethanolaminesPlatelet Activating FactorRatsArachidonic AcidDocosahexaenoic AcidsEicosapentaenoic AcidPhosphatidylcholinesPhosphatidylethanolaminesPhospholipidsPlatelet Activating FactorAtopic dermatitisDHAEPAPlatelet-activating factorSquid phospholipidsTodarodes pacificus

Identifiers

PMID39804492

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.