Evidence map›Paper›PMID 39804544›Full record

ArticleHead and neck pathology2025

NAB2::STAT6 Rearranged Carcinoma of the Parotid Gland with Sebaceous Differentiation: A Case Report.

Emma J de Ruiter, Johannes A Rijken, Thom Doeleman, Lennart A Kester, Frank A Pameijer, Mihaela G Raicu, Gerben E Breimer

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emma J de RuiterDepartment of Pathology, University Medical Center Utrecht, Utrecht, 3508 GA, The Netherlands. e.j.deruiter-2@umcutrecht.nl.ORCID http://orcid.org/0000-0003-0369-8267
Johannes A RijkenDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Thom DoelemanDepartment of Pathology, University Medical Center Utrecht, Utrecht, 3508 GA, The Netherlands.
Lennart A KesterDepartment of Pathology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Frank A PameijerDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Mihaela G RaicuPathology DNA BV, location St Antonius Hospital, Nieuwegein, The Netherlands.
Gerben E BreimerDepartment of Pathology, University Medical Center Utrecht, Utrecht, 3508 GA, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe NAB2::STAT6 fusion is predominantly associated with solitary fibrous tumors (SFTs) and is utilized in diagnosing SFTs through nuclear STAT6 protein overexpression. Recent studies expanded the phenotypic spectrum of NAB2::STAT6 rearranged neoplasms, including adamantinoma-like and teratocarcinosarcoma-like phenotypes. We report a case of a NAB2::STAT6 rearranged epithelial tumor exhibiting sebaceous differentiation in the parotid gland.

methodsFine-needle aspiration (FNA), histopathology, immunohistochemistry, and molecular studies of this case were described.

resultsFine-needle aspiration (FNA) revealed atypical basaloid cells, suggesting primary salivary gland carcinoma or metastasis. Histological examination showed basaloid-squamous cells with a monomorphic appearance containing foci of sebaceous differentiation, expressing pancytokeratin, p40, and androgen receptor, while CD34 staining was negative. Molecular studies identified a NAB2::STAT6 fusion, along with an AKT1 mutation.

conclusionThis case further expands the phenotypic spectrum of NAB2::STAT6 rearranged neoplasms and emphasizes comprehensive histopathological and molecular analysis in challenging head and neck tumors. It suggests STAT6 immunohistochemistry as a potential screening tool for head and neck tumors resembling sebaceous carcinoma, myoepithelial tumors, or GLI1-altered neoplasms.

Indexed as

Parotid NeoplasmsRepressor ProteinsSTAT6 Transcription FactorBiomarkers, TumorCarcinomaGene RearrangementHumansBiomarkers, TumorNAB2 protein, humanRepressor ProteinsSTAT6 protein, humanSTAT6 Transcription FactorMolecular diagnosticsNAB2::STAT6Salivary glandSolitary fibrous tumorSTAT6

Identifiers

PMID39804544
PMCPMC11730034

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.