Evidence map›Paper›PMID 39805914›Full record

ArticleScientific reports2025

The known genetic variants of BRCA1, BRCA2 and NOD2 in pancreatitis and pancreatic cancer risk assessment.

Jarosław Matykiewicz, Wioletta Adamus-Białek, Monika Wawszczak-Kasza, Bartosz Molasy, Magdalena Kołomańska, Rusłan Oblap, Łukasz Madej, Dorota Kozieł, Stanisław Głuszek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jarosław MatykiewiczInstitute of Medical Sciences, Jan Kochanowski University of Kielce, Kielce, Poland.
Wioletta Adamus-BiałekInstitute of Medical Sciences, Jan Kochanowski University of Kielce, Kielce, Poland. wioletta.adamus-bialek@ujk.edu.pl.
Monika Wawszczak-KaszaInstitute of Medical Sciences, Jan Kochanowski University of Kielce, Kielce, Poland.
Bartosz MolasyInstitute of Medical Sciences, Jan Kochanowski University of Kielce, Kielce, Poland.
Magdalena KołomańskaInstitute of Medical Sciences, Jan Kochanowski University of Kielce, Kielce, Poland.
Rusłan OblapInstitute of Medical Sciences, Jan Kochanowski University of Kielce, Kielce, Poland.
Łukasz MadejInstitute of Medical Sciences, Jan Kochanowski University of Kielce, Kielce, Poland.
Dorota KoziełInstitute of Medical Sciences, Jan Kochanowski University of Kielce, Kielce, Poland.
Stanisław GłuszekInstitute of Medical Sciences, Jan Kochanowski University of Kielce, Kielce, Poland.

Funding

Jan Kochanowski University of Kielce, Poland SUPS.RN.24.015
6 · The paper itself

Abstract

The single nucleotide polymorphism in NOD2 (rs2066847) is associated with conditions that may predispose to the development of gastrointestinal disorders, as well as the known BRCA1 and BRCA2 variants classified as risk factors in many cancers. In our study, we analyzed these variants in a group of patients with pancreatitis and pancreatic cancer to clarify their role in pancreatic disease development. The DNA was isolated from whole blood samples of 553 patients with pancreatitis, 83 patients with pancreatic cancer, 44 cases of other pancreatic diseases, and 116 healthy volunteers. The NOD2 (rs2066847), BRCA1 (rs80357914) and BRCA2 (rs276174813) were genotyped. The statistically significant 3-fold increased risk of pancreatic cancer was detected among the patients with rs2066847 polymorphism (OR = 2.77, p-value = 0.019). We did not find the studied polymorphisms in BRCA1 (rs80357914) and BRCA2 (rs276174813). However, the adjacent polymorphisms have been detected only in patients with pancreatic diseases. The studied variant in NOD2 occurs more frequently in pancreatic patients and significantly increases the risk of pancreatic cancer. It can be considered as a genetic risk factor that predisposes to cancer development. The analyzed regions in BRCA1 and BRCA2 may be a potential target in further search for a genetic marker of pancreatic diseases.

Indexed as

BRCA1 ProteinBRCA2 ProteinGenetic Predisposition to DiseaseNod2 Signaling Adaptor ProteinPancreatic NeoplasmsPancreatitisPolymorphism, Single NucleotideAdultAgedCase-Control StudiesFemaleGenotypeHumansMaleMiddle AgedRisk AssessmentBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanNOD2 protein, humanNod2 Signaling Adaptor ProteinBRCA1BRCA2NOD2Pancreatic cancerPancreatitis

Identifiers

PMID39805914
PMCPMC11729861

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.