ArticleCardiovascular diabetology2025
Triglyceride-glucose index: carotid intima-media thickness and cardiovascular risk in a European population.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Association between the triglyceride-glucose-body mass index and the risk of early vascular aging in young and middle-aged Chinese adults: a cross-sectional study.BMC cardiovascular disorders · 2026Observational
- The association between triglyceride glucose-frailty index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study.Cardiovascular diabetology · 2026Article
- Triglyceride glucose index and modified triglyceride glucose indices are instrumental to optimize 3P medical management for postpartum cardiovascular disease.The EPMA journal · 2026Article
- Concurrent high-intensity interval plus resistance training improves vascular health in breast cancer survivors with high chemotherapy exposure.Biological research · 2026Article
- Association between the newly proposed triglyceride glucose-a body shape index (TyG-ABSI) and atherosclerotic cardiovascular disease in the general population: modest diagnostic improvement compared with traditional TyG-related parameters.Cardiovascular diabetology · 2026Article
- Association between triglyceride-glucose index-a body shape index and atherosclerotic cardiovascular disease, and the modification effect of dietary patterns.Frontiers in nutrition · 2026Article
- Reciprocal mediation of immuno-inflammation and insulin resistance in the risk of chronic kidney disease among patients with coronary artery disease: insights from neutrophil-to-lymphocyte ratio and triglyceride-glucose index.Frontiers in immunology · 2026Article
- The impact of metabolic syndrome and triglyceride-glucose index on the risk of in-stent restenosis after percutaneous coronary intervention: a retrospective study.Frontiers in cardiovascular medicine · 2026Article
- Association between triglyceride-glucose index combined with a body shape index and atherosclerotic cardiovascular disease risk varies by glycemic status: insights from the UK Biobank.Cardiovascular diabetology · 2025Article
- Association of Non-Insulin-Based Insulin Resistance Indices With Risk of Incident Valvular Heart Disease: Results From the UK Biobank Cohort Study.Journal of the American Heart Association · 2025Article
- Triglyceride-glucose index in the associations between chronic low-grade inflammation and carotid intima-media thickness: mediation and effect-modification across triglyceride-glucose strata.BMC cardiovascular disorders · 2025Article
- The Association Between the Triglyceride-Glucose Index and the Risk of Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.Life (Basel, Switzerland) · 2025Article
- Association Between Carotid Intima-Media Thickness and Novel Lipid Parameters in Hypertensive Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Association between estimated glucose disposal rate and the risk of atherosclerotic cardiovascular disease: insight from cross-sectional and retrospective cohort studies.Frontiers in nutrition · 2025Article
- Longitudinal TyG-BMI trajectories predict carotid atherosclerosis progression in a Chinese retrospective cohort.Frontiers in cardiovascular medicine · 2025Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe triglyceride-glucose (TyG) index is now widely recognized as a marker of insulin resistance and has been linked to the development and prognosis of atherosclerotic cardiovascular diseases (ASCVD) in numerous populations, particularly in the Eastern world. Although there are fewer reports from the Western world, and they are sometimes contradictory, the absence of definitive data on the relationship between a raised TyG index and cardiovascular risk suggested the opportunity of testing this biochemical marker against a well-established vascular marker such as the carotid intima media thickness (c-IMT).
methodsPrimary prevention patients were selected from a cohort of individuals who underwent c-IMT measurement between 1984 and 2018 at the Dyslipidemia Center at the ASST Grande Ospedale Metropolitano Niguarda in Milan, Italy. The TyG index was calculated as the Ln [fasting TG (mg/dL)×fasting glucose (mg/dL)/2]. Carotid ultrasonography was performed using echographic measurements of the far walls of the left and right common, internal carotids, and bifurcations. Patients were followed for up to 20 years with periodic evaluation of biochemical parameters. ASCVD events were monitored through hospital records, where all patients were regularly examined.
resultsThe analysis included 3108 individuals with a mean age of 54.9 ± 13.1 years. Participants were generally non-obese, with an average BMI of 24.6 ± 3.5 Kg/m
conclusionsTyG index is a sensitive marker of risk in a European population with moderate ASCVD risk, as assessed by c-IMT measurements, in a large cohort of Lipid Clinic patients.
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