Evidence map›Paper›PMID 39808111›Full record

ArticleACS infectious diseases2025

Stereospecific Resistance to N2-Acyl Tetrahydro-β-carboline Antimalarials Is Mediated by a PfMDR1 Mutation That Confers Collateral Drug Sensitivity.

Emily K Bremers, Joshua H Butler, Leticia S Do Amaral, Emilio F Merino, Hanan Almolhim, Bo Zhou, Rodrigo P Baptista, Maxim Totrov, Paul R Carlier, Maria Belen Cassera

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Identification of an Orally Efficacious Imidazo[4,5-Journal of medicinal chemistry · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emily K BremersDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-9768-0211
Joshua H ButlerDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.
Leticia S Do AmaralDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-2861-216X
Emilio F MerinoDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-5400-7377
Hanan AlmolhimDepartment of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.
Bo ZhouDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID 0009-0001-5603-4221
Rodrigo P BaptistaDepartment of Medicine, Houston Methodist Research Institute, Houston, Texas 77030, United States.
Maxim TotrovMolSoft LLC, San Diego, California 92121, United States.ORCID 0000-0001-8594-274X
Paul R CarlierDepartment of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0002-6683-285X
Maria Belen CasseraDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0001-6341-3169

Funding

Training in Tropical and Emerging Global Diseases - SupplementT32AI060546 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI Silvia N Moreno, Vasant Muralidharan · 2004 to 2026
$5.1M
Optimization of antimalarials targeting multiple life stages of the parasiteR01AI157445 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Paul R Carlier, Maria Belen Cassera · 2021 to 2026
$4.5M
Understanding Plasmodium falciparum's multidrug resistance protein through the characterization of a novel antimalarial class.F31AI181461 · NIAID · UNIVERSITY OF GEORGIA · PI BREMERS, EMILY KARA · 2024 to 2025
$94k
NIAID NIH HHS F31 AI181461NIAID NIH HHS R01 AI157445NIAID NIH HHS T32 AI060546
6 · The paper itself

Abstract

Half the world's population is at risk of developing a malaria infection, which is caused by parasites of the genus

Indexed as

AntimalarialsATP-Binding Cassette, Sub-Family C ProteinsCarbolinesDrug ResistancePlasmodium falciparumHumansMutationPolymorphism, Single NucleotideAntimalarialsATP-Binding Cassette, Sub-Family C ProteinsCarbolinesMdr1 protein, Plasmodium falciparumcollateral drug sensitivitydrug resistancemalariaPfMDR1Plasmodium falciparumtetrahydro-β-carbolines

Identifiers

PMID39808111
PMCPMC11828674

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.