Evidence map›Paper›PMID 39809244›Full record

ReviewHormone research in paediatrics2026

Epigenetics of Childhood Obesity.

Maria Keller, Mandy Vogel, Antje Garten, Stina Ingrid Alice Svensson, Elena Rossi, Peter Kovacs, Yvonne Böttcher, Wieland Kiess

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hormone research in paediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cells · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria KellerMedical Department III - Endocrinology, Nephrology, Rheumatology, Medical Center, University of Leipzig, Leipzig, Germany.
Mandy VogelHospital for Children and Adolescents, LIFE Child, University of Leipzig, Leipzig, Germany.
Antje GartenHospital for Children and Adolescents, Center for Pediatric Research, University of Leipzig, Leipzig, Germany.
Stina Ingrid Alice SvenssonDepartment of Clinical Molecular Biology, EpiGen, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Elena RossiHospital for Children and Adolescents, LIFE Child, University of Leipzig, Leipzig, Germany, elena.rossi@medizin.uni-leipzig.de.
Peter KovacsMedical Department III - Endocrinology, Nephrology, Rheumatology, Medical Center, University of Leipzig, Leipzig, Germany.
Yvonne BöttcherDepartment of Clinical Molecular Biology, EpiGen, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Wieland KiessHospital for Children and Adolescents, LIFE Child, University of Leipzig, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildhood obesity has become a global pandemic and is one of the strongest risk factors for cardiovascular disease later in life. The correlation of epigenetic marks with obesity and related traits is being elucidated. This review summarizes the latest research and its challenges in the study of epigenetics of (childhood) obesity. SUMMARY: Epigenome-wide association studies helped identify novel targets and methylation sites that are important in the pathophysiology of obesity. In the future, such sites will become essential for developing methylation risk scores (MRS) for metabolic and cardiovascular diseases. Although MRS are very promising for predicting the individual risk of obesity, the implementation of MRS is challenging and has not been introduced into clinical practice so far. KEY MESSAGES: Future research will undoubtedly discover numerous methylation sites that may be involved in the development of obesity and its comorbidities, especially at a young age. This will contribute to a better understanding of the complex etiology of human obesity. From a clinical perspective, the overarching aim was to generate MRS that is robust for reliable and accurate prediction of obesity and its comorbidities.

Indexed as

DNA MethylationEpigenesis, GeneticPediatric ObesityChildHumansCardiovascular riskChildhoodEpigeneticsMethylation risk scoresObesity

Identifiers

PMID39809244
PMCPMC13012772

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.