Evidence map›Paper›PMID 39809343›Full record

Trial reportContemporary clinical trials2025

Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION) - A randomized comparative-effectiveness study of two remotely delivered mind-body interventions for older adults with cognitive decline.

Linda L Chao, Deborah E Barnes, Margaret A Chesney, Wolf E Mehling, Jennifer A Lee, Cynthia Benjamin, Helen Lavretsky, Linda Ercoli, Prabha Siddarth, Katherine L Narr

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05217849 (Multi-domain Online Therapeutic Investigation Of Neurocognition), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05217849 nacompletednot on this map

Multi-domain Online Therapeutic Investigation Of Neurocognition

TypeinterventionalSponsorUniversity of California, San FranciscoRan2022 to 2025Enrolled77ConditionsMild Cognitive Impairment, Subjective Memory DeclineArmsTai Chi, Preventing Loss of Independence through Exercise (PLIE), Health and Wellness Education
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Linda L ChaoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, United States of America; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, United States of America; San Francisco Veterans Affairs Health Care System, San Francisco, CA, United States of America. Electronic address: Linda.Chao@ucsf.edu.
Deborah E BarnesDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, United States of America; Department of Epidemiology and Biostatistics, University of California, San Francisco, United States of America.
Margaret A ChesneyOsher Center for Integrative Medicine, University of California, San Francisco, United States of America; Department of Medicine, University of California, San Francisco, United States of America.
Wolf E MehlingOsher Center for Integrative Medicine, University of California, San Francisco, United States of America; Department of Family and Community Medicine, University of California, San Francisco, United States of America.
Jennifer A LeeTogether Senior Health, San Francisco, CA, United States of America.
Cynthia BenjaminTogether Senior Health, San Francisco, CA, United States of America.
Helen LavretskyDepartment of Psychiatry, Semel Institute for Neuroscience and Behavior, University of California, Los Angeles, United States of America.
Linda ErcoliDepartment of Psychiatry, Semel Institute for Neuroscience and Behavior, University of California, Los Angeles, United States of America.
Prabha SiddarthDepartment of Psychiatry, Semel Institute for Neuroscience and Behavior, University of California, Los Angeles, United States of America.
Katherine L NarrDepartment of Neurology, University of California, Los Angeles, United States of America.

Funding

CSRD VA IK6 CX002522
6 · The paper itself

Abstract

backgroundResearch suggest that mind-body movement programs have beneficial effects on cognitive outcomes for older adults with cognitive decline. However, few studies have directly compared specific approaches to mind-body movement or studied the impact of remote program delivery.

methodsIn a 3-arm randomized controlled trial (RCT) for older adults with cognitive impairment, we are comparing a multidomain mind-body program that emphasizes movement, body awareness, personal meaningfulness, and social connection, and a traditional Chinese mind-body exercise (Tai Chi) to a health and wellness education control condition. All 3 interventions are delivered remotely two times per week (onehour per session) for 12 weeks. The two active interventions are live-streamed. Outcomes are assessed prior to, after, and 6-months after the interventions. The co-primary outcomes are changes on the Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog) and brain functional connectivity in the Default Mode Network (DMN). Secondary outcomes include measures of specific cognitive domains (e.g., executive function, attention), mobility, and self-report measures of general well-being, quality of life, social engagement, self- and attention-regulation.

conclusionThis RCT will directly compare the effects of two mind-body movement programs versus an education control delivered remotely over 12 weeks on cognitive, neuroimaging, and participant-reported outcomes. If successful, these programs may provide scalable strategies for slowing cognitive decline, which could potentially delay dementia onset in some individuals. TRIAL REGISTRATION ID: NCT05217849.

Indexed as

Cognitive DysfunctionMind-Body TherapiesTai JiAgedCognitionComparative Effectiveness ResearchFemaleHumansMaleQuality of LifeAgingCognitive dysfunctionExercise therapyMemory disordersMild cognitive impairmentMind-body therapiesSubjective memory decline

Identifiers

PMID39809343
PMCPMC11887397

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.