Evidence map›Paper›PMID 39809571›Full record

ReviewFEMS microbiology reviews2025

The impact of phenotypic heterogeneity on fungal pathogenicity and drug resistance.

Lukasz Kozubowski, Judith Berman

Abstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lukasz KozubowskiEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, 29634, USA.ORCID 0000-0002-9560-782X
Judith BermanShmunis School of Biomedical and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.

Funding

The role of septins in the adaptation of Cryptococcus neoformans to host temperature in HIV-based cryptococcosisR01AI167692 · NIAID · CLEMSON UNIVERSITY · PI Lukasz Kozubowski · 2022 to 2026
$1.9M
Mechanisms of Fluconazole-Induced Aneuploidy in Cryptococcus NeoformansR15AI119801 · NIAID · CLEMSON UNIVERSITY · PI KOZUBOWSKI, LUKASZ · 2015 to 2015
$437k
Division of Intramural Research, National Institute of Allergy and Infectious DiseasesEuropean Research Council 951475Israel Science Foundation #997/18Ministry of Health, State of Israel #3000018841National Science Foundation #2203847NIAID NIH HHS R01 AI167692NIAID NIH HHS R15 AI119801NIH HHS R01AI167692
6 · The paper itself

Abstract

Phenotypic heterogeneity in genetically clonal populations facilitates cellular adaptation to adverse environmental conditions while enabling a return to the basal physiological state. It also plays a crucial role in pathogenicity and the acquisition of drug resistance in unicellular organisms and cancer cells, yet the exact contributing factors remain elusive. In this review, we outline the current state of understanding concerning the contribution of phenotypic heterogeneity to fungal pathogenesis and antifungal drug resistance.

Indexed as

Antifungal AgentsDrug Resistance, FungalFungiGenetic HeterogeneityHumansMycosesPhenotypeVirulenceAntifungal Agentsantifungal drugsdrug resistancefungal pathogenesisfungimedical mycologyphenotypic heterogeneity

Identifiers

PMID39809571
PMCPMC11756289

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.