Evidence map›Paper›PMID 39809918›Full record

ArticleNPJ digital medicine2025

Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data.

Milena Engelke, Jorge Piano Simões, Laura Basso, Nina Wunder, Berthold Langguth, Thomas Probst, Rüdiger Pryss, Winfried Schlee

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Tinnitus Measured in Everyday Life: A Literature Review of Ecological Momentary Assessment Studies.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Milena EngelkeDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany. milena.engelke@ukr.de.ORCID http://orcid.org/0000-0002-7346-0441
Jorge Piano SimõesDepartment of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.ORCID http://orcid.org/0000-0003-3397-2319
Laura BassoDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Nina WunderDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Berthold LangguthDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.ORCID http://orcid.org/0000-0002-7066-510X
Thomas ProbstDepartment of Psychology, Paris Lodron University Salzburg, Salzburg, Austria.ORCID http://orcid.org/0000-0002-6113-2133
Rüdiger PryssInstitute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0003-1522-785X
Winfried SchleeDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.ORCID http://orcid.org/0000-0001-7942-1788

Funding

EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 848261
6 · The paper itself

Abstract

Intensive longitudinal sampling enhances subjective data collection by capturing real-time, dynamic inputs in natural settings, complementing traditional methods. This study evaluates the feasibility of using daily self-reported app data to assess clinical improvement among tinnitus patients undergoing treatment. App data from a multi-center randomized clinical trial were analysed using time-series feature extraction and nested cross-validated ordinal regression with elastic net regulation to predict clinical improvement based on the Clinical Global Impression-Improvement scale (CGI-I). With 50% app compliance (N = 129, 8480 entries), the model demonstrated good fit to the test data (McFadden R2 = 0.82) suggesting its generalizability. Clinical improvement was associated with linear declines in tinnitus-related thoughts, jaw tension, tinnitus loudness, increases in happiness, and variability changes in tinnitus loudness and distress. These findings suggest that daily self-reported data on tinnitus symptoms is sensitive to treatment response and provides insights into specific symptom changes that occur during treatment.

Identifiers

PMID39809918
PMCPMC11733005

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.