Evidence map›Paper›PMID 39809995›Full record

ReviewInnere Medizin (Heidelberg, Germany)2025

[Functional disorders in chronic inflammatory bowel disease: the gut-brain axis].

Stefan Begré, Mark Fox, Sebastian Bruno Ulrich Jordi, Benjamin Misselwitz

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Innere Medizin (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stefan BegréISFOM - Institut für Stressfolgeerkrankungen und Stressmanagement, Weinbergstrasse 139, Zürich, Schweiz, 8006. stefan.begre@ztpz.ch.
Mark FoxKlinik für Gastroenterologie und Hepatologie, Universitätsspital Zürich, Zürich, Schweiz.
Sebastian Bruno Ulrich JordiUniversitätsklinik für Viszerale Medizin und Chirurgie, Department für Klinische Forschung, Inselspital Bern, Universitätsspital Bern, Bern, Schweiz.
Benjamin MisselwitzMedizinische Klinik 2, Ludwig-Maximilians-Universität München, Marchioninistraße 15, 83477, München, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn patients with inflammatory bowel diseases (IBD), functional complaints frequently persist after the clearing of inflammation and are clinically difficult to distinguish from symptoms of inflammation. In recent years, the influence of bidirectional communication between the gut and brain on gut physiology, emotions, and behavior has been demonstrated. RESEARCH QUESTIONS: What mechanisms underlie the development of functional gastrointestinal complaints in patients with irritable bowel syndrome (IBS) and IBD? What therapeutic approaches arise from this? MATERIALS AND

methodsNarrative review.

resultsThe pathogenesis of IBS involves interactions between psychosocial factors, genetics, and microbiota as well as the central and peripheral nervous systems. The interplay between stress and visceral hypersensitivity is of central importance. Therapeutically, lifestyle changes with stress reduction and exercise alongside dietary, pharmacological, and psychotherapeutic options are useful. DISCUSSION: The treatment of functional gastrointestinal disorders remains challenging, as pharmacological therapies are often ineffective and gut-directed psychotherapies are rarely available.

Indexed as

BrainBrain-Gut AxisGastrointestinal TractInflammatory Bowel DiseasesChronic DiseaseGastrointestinal MicrobiomeHumansIrritable Bowel SyndromeStress, PsychologicalAnxietyDepressionInflammatory bowel diseases/physiopathologyIrritable bowel syndromeStress, psychological

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.