Evidence map›Paper›PMID 39810084›Full record

ArticleBMC genomics2025

Comparative analysis of the whole transcriptome landscapes of muscle and adipose tissue in Qinchuan beef cattle.

Ju Qiu, Zheng Ma, Zhipeng Hong, Xu Yin, Yun Chen, Hafiz Qadeer Ahmed, Linsen Zan, Anning Li

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  4. Article
  5. Article
  6. Article
  7. Article
  8. Veterinary world · 2025
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ju QiuCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Zheng MaCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Zhipeng HongCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Xu YinCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Yun ChenCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Hafiz Qadeer AhmedCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Linsen ZanCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Anning LiCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China. lianning@nwafu.edu.cn.

Funding

National Key Research and Development Project of China No. 2023YFD1300101National Natural Science Foundation of China No. 32172703
6 · The paper itself

Abstract

backgroundMuscle and adipose tissue are the most critical indicators of beef quality, and their development and function are regulated by noncoding RNAs (ncRNAs). However, the differential regulatory mechanisms of ncRNAs in muscle and adipose tissue remain unclear.

resultsIn this study, 2,343 differentially expressed mRNAs (DEMs), 235 differentially expressed lncRNAs (DELs), 95 differentially expressed circRNAs (DECs) and 54 differentially expressed miRNAs (DEmiRs) were identified in longissimus dorsi muscle (LD), subcutaneous fat (SF) and perirenal fat (VF) in Qinchuan beef cattle. The results of functional enrichment analysis showed that DEMs, DELs, DECs and DEmiRs were enriched in biological processes related to development and function of muscle and fat deposition, including skeletal muscle contraction, muscle organ development, PPAR signaling pathway, fatty acid metabolism and MAPK signaling pathway. Based on the competing endogenous RNA (ceRNA) regulatory mechanism, we constructed a lncRNA/circRNA-miRNA-mRNA network consisting of 6 circRNAs, 5 lncRNAs, 6 miRNAs and 27 mRNAs. Among them, 55 ceRNA axes were involved, including circRNA12990 - bta-miR-133a_L-1R + 1 - MYO6/ZEB2, circRNA2893/MSTRG.28538.1/MSTRG.11613.4 - pma-miR-145-5p_R + 2 - EYA4 and MSTRG.26982.1 - bta-let-7e_R + 1 - RBM40.

conclusionsThis study identified a group of differentially expressed mRNAs, lncRNAs, circRNAs and miRNAs between muscle and adipose tissue and constructed a potential ceRNA regulatory network, which may serve as a foundation for studying the differential regulatory roles of ncRNAs in the development and function of muscle and adipose tissue.

Indexed as

Adipose TissueGene Expression ProfilingMuscle, SkeletalTranscriptomeAnimalsCattleGene Regulatory NetworksMicroRNAsRNA, CircularRNA, Long NoncodingRNA, MessengerMicroRNAsRNA, CircularRNA, Long NoncodingRNA, MessengerAdiposeceRNAMuscleQinchuan beef cattleRNA-seq

Identifiers

PMID39810084
PMCPMC11731550

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.