Evidence map›Paper›PMID 39811568›Full record

ArticleCerebral circulation - cognition and behavior2025

Cumulative blood pressure load and cognitive decline in older adults: An observational analysis of two large cohorts.

Ying Xu, G Peggy McFall, Lina Rydén, Johan Skoog, Edward Chang, Lucette A Cysique, Katie Harris, Sarah Kedwell, Mei Ling Lim, Kaarin J Anstey and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral circulation - cognition and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ying XuThe George Institute for Global Health, Sydney, Australia.
G Peggy McFallDepartment of Psychology (Science), University of Alberta, Alberta, Canada.
Lina RydénDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.
Johan SkoogDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.
Edward ChangUniversity of Sydney Medical School, The University of Sydney, Sydney, Australia.
Lucette A CysiqueThe Kirby Institute, Sydney, Australia.
Katie HarrisThe George Institute for Global Health, Sydney, Australia.
Sarah KedwellThe George Institute for Global Health, Sydney, Australia.
Mei Ling LimThe George Institute for Global Health, Sydney, Australia.
Kaarin J AnsteySchool of Psychology, University of New South Wales, Sydney, Australia.
Craig S AndersonThe George Institute for Global Health, Sydney, Australia.
Roger A DixonDepartment of Psychology (Science), University of Alberta, Alberta, Canada.
Ingmar SkoogDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.
Phillip J TullyUniversity of New England, Armidale, Australia.
Ruth PetersThe George Institute for Global Health, Sydney, Australia.

Funding

Longitudinal Study of Cognitive AgingR37AG008235 · NIA · UNIVERSITY OF ALBERTA · PI DIXON, ROGER A · 2002 to 2011
$2.4M
LONGITUDINAL STUDY OF COGNITIVE AGINGR01AG008235 · NIA · UNIVERSITY OF VICTORIA · PI DIXON, ROGER A · 1989 to 2017
$2.3M
NIA NIH HHS R01 AG008235NIA NIH HHS R37 AG008235
6 · The paper itself

Abstract

Introduction: Cumulative blood pressure metrics may provide greater precision for measuring temporal risk exposure, especially in later life where data are mixed regarding associations of high blood pressure (BP) on cognitive function. We examined the relationship between greater cumulative exposure to high BP in later life and several domains of cognitive function. Methods: Individual cognitive assessment scores and BP measurements in older adults (age ≥70 years) at baseline and over approximately 8 years of follow-up were available in the population-based Canadian Victoria Longitudinal Study (VLS) and Swedish Gothenburg H70 Birth Cohort Studies (H70). Linear mixed models were used to quantify associations between cumulative systolic and diastolic BP and change in cognitive scores. Results: Each additional 100mmHg increase in cumulative BP was related to greater decline in the Rey Auditory Verbal Learning Test (RAVLT) List A, trials 1-5 total score over follow-up: -0.23 (95% confidence interval [CI] -0.32, -0.13) for systolic BP and -0.41 (95%CI -0.58, -0.23) for diastolic BP. Similarly increases cumulative systolic and diastolic BP were related to greater declines Digit Symbol Substitution Task (DSS) scores: -0.59 (95%CI -0.80, -0.38) and -1.04 (95% CI -1.40, -0.67), respectively. There were no associations of cumulative BP and temporal changes in general cognition, other measures of verbal episodic memory, or semantic fluency. Conclusions: Higher cumulative BP is associated with greater declines in RAVLT measured immediate memory span and complex attention, information processing speed and visuospatial scanning in older adults, but the scale of change is small. Additional research is required to further define these relationships and identify opportunities for prevention.

Indexed as

Blood pressureCognitive declineCohortOld adults

Identifiers

PMID39811568
PMCPMC11730254

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.