Evidence map›Paper›PMID 39812596›Full record

ArticleAging2025

The comparison of serum bone-turnover markers in different stage of chronic kidney disease and the associated impact of intradialytic cycling in patients with end-stage renal disease.

Yi-Chou Hou, Chia-Ter Chao, Li-Jane Shih, Kuo-Wang Tsai, Shyh-Min Lin, Ruei-Ming Chen, Kuo-Cheng Lu

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yi-Chou HouDepartment of Internal Medicine, Division of Nephrology, Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Chia-Ter ChaoDepartment of Internal Medicine, Nephrology division, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Li-Jane ShihDepartment of Medical Laboratory, Taoyuan Armed Forces General Hospital, Longtan, Taoyuan 325, Taiwan.
Kuo-Wang TsaiDepartment of Medical Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Shyh-Min LinDepartment of Medicine, Division of Radiology, Cardinal-Tien Hospital, New Taipei City 231, Taiwan.
Ruei-Ming ChenGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Kuo-Cheng LuDepartment of Medicine, Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBone turnover markers reflected the bone remodeling process and bone health in clinical studies. Studies on variation of bone remodeling markers in different stage CKD were scant, and this study investigated the role of bedside intradialytic cycling in altering concentrations of bone-remodeling markers in patients with end-stage renal disease (ESRD). MATERIALS AND

methodsParticipants were segmented into four groups: a group with eGFR >60 ml/min/1.73 m

resultsBone-formative marker levels (bone-specific alkaline phosphatase and procollagen type 1 amino-terminal propeptide, P1NP) were higher in ESRD patients than in non-ESRD patients and were correlated with indoxyl sulfate and intact parathyroid hormone concentrations (

conclusionBone-formative marker concentrations increased with the severity of chronic kidney disease. Bone formative markers concentration increased along with CKD severity. We demonstrated the bone resorptive markers tartrate-resistant acid phosphatase-5b and N-terminal telopeptide-1 increased after intradialytic cycling in ESRD patients.

Indexed as

Bone RemodelingKidney Failure, ChronicRenal DialysisRenal Insufficiency, ChronicAdultAgedAlkaline PhosphataseBiomarkersExercise TherapyFemaleHumansMaleMiddle AgedPeptide FragmentsProcollagenAlkaline PhosphataseBiomarkersPeptide FragmentsProcollagenprocollagen Type I N-terminal peptidebone turnoverend-stage renal diseaseintradialytic cyclingN-terminal telopeptide-1osteoporosistartrate-resistant acid phosphatase-5b

Identifiers

PMID39812596
PMCPMC11810069

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.