Evidence map›Paper›PMID 39812690›Full record

Observational studyJournal of neurology2025

Dysregulation of the molecular clock by blood-borne factors in Alzheimer's disease patients.

Chunsong Zhao, Taoran Li, Shuwen Hao, Lifang Zhao, Ying Han, Yanning Cai

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03370744 (Prediction of Cognitive Decline by Neuroimaging Techniques and the Application in Diagnosis and Treatment of Preclinical AD), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03370744 completednot on this map

Prediction of Cognitive Decline by Neuroimaging Techniques and the Application in Diagnosis and Treatment of Preclinical AD (Sino Longitudinal Study on Cognitive Decline, SILCODE)

TypeobservationalSponsorXuanwuH 2Ran2017 to 2022Enrolled300ConditionsSubjective Cognitive Decline, Preclinical Alzheimer's DiseaseArmsNeuropsychological scale
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chunsong Zhao *Department of Central laboratory, Xuanwu Hospital of Capital Medical University, Beijing, 100053, P.R. China.
Taoran Li *Jiangsu Province Hospital, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, P.R. China.
Shuwen HaoDepartment of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, 050030, Hebei, P.R. China.
Lifang ZhaoDepartment of Central laboratory, Xuanwu Hospital of Capital Medical University, Beijing, 100053, P.R. China. zhaolifang@xwhosp.org.
Ying HanSchool of Biomedical Engineering, Hainan University, Haikou, 570228, Hainan, P.R. China. hanying@xwh.ccmu.edu.cn.
Yanning CaiDepartment of Central laboratory, Xuanwu Hospital of Capital Medical University, Beijing, 100053, P.R. China. Yanningcai@hotmail.com.ORCID http://orcid.org/0000-0003-0879-9809

Funding

Beijing Translational Medicine Promotion Project YC202301QX0148Key Technologies Research and Development Program of Anhui Province 2021YFC2501205the National Nature Science Foundation of China 82020108013the STI2030-Major Project 2021ZD0201101the STI2030-Major Project 2022ZD0211800
6 · The paper itself

Abstract

backgroundCircadian disruptions are increasingly recognized in Alzheimer's disease (AD) patients and may influence disease onset and progression. This study examines how AD pathology affects blood-borne factors that regulate circadian rhythms.

methodsEighty-five participants from the Sino Longitudinal Study on Cognitive Decline were enrolled: 35 amyloid-beta negative normal controls (Aβ- NCs), 23 amyloid-beta positive normal controls (Aβ+ NCs), 15 patients with amnestic mild cognitive impairment (aMCI), and 12 with Alzheimer's disease dementia (ADD). Patients with aMCI and ADD were grouped as cognitively impaired (CI). Cellular circadian period length was assessed using a serum-based assay. Expression levels of clock genes in serum-treated cells and in leukocytes of participants were measured via real-time PCR. Plasma biomarkers were quantified using a single-molecule array immunoassay. Pineal parenchymal and hippocampal volumes were determined by magnetic resonance imaging.

resultsThe cellular circadian period length was significantly extended by serum from CI patients than by that from Aβ- NCs (p < 0.01). Treatment of cells with serum from the CI patients resulted in suppressed expression of the clock genes Bmal1 and Nr1d1. Strong relationships between the expression levels of clock genes observed in leukocytes of the Aβ- NC group did not appear in those of the Aβ+ NC or CI groups. The significant correlation of cellular circadian period length and the pineal volume was only observed in the Aβ- NC group, but not in the Aβ+ NC or CI groups.

conclusionsThis study indicates the presence of significant changes in blood-borne factors that could affect the circadian rhythms in AD, starting even at preclinical stages. These alterations could precede cognitive decline and contribute to AD pathogenesis.

trial registrationThe cohort is registered at ClinicalTrials.gov (SILCODE: NCT03370744; Registered on Mar 15

Indexed as

Alzheimer DiseaseCircadian RhythmCognitive DysfunctionAgedAged, 80 and overAmyloid beta-PeptidesARNTL Transcription FactorsBiomarkersCLOCK ProteinsFemaleHippocampusHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedAmyloid beta-PeptidesARNTL Transcription FactorsBiomarkersCLOCK ProteinsAlzheimer’s diseaseAβBlood-borne factorsCircadian rhythmCognitively impairedPineal parenchymal volume

Identifiers

PMID39812690

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.