Evidence mapPaperPMID 39814410Full record

ReviewPhysiological reviews2025

NADPH oxidases: redox regulation of cell homeostasis and disease.

Damir Kračun, Lucia Rossetti Lopes, Eugenia Cifuentes-Pagano, Patrick J Pagano

Abstract readReview
In one paragraph

Review in Physiological reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Review
  2. Article
  3. Toxicity of the Covalent Organic Framework Material TpPa to Zebrafish.Animals : an open access journal from MDPI · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. MnVeterinary sciences · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Enzyme-Integrated Hydrogels for Advanced Biological Applications.Polymer science & technology (Washington, D.C.) · 2026
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Damir KračunPittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-1821-7860
Lucia Rossetti LopesDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID 0000-0003-0530-7805
Eugenia Cifuentes-PaganoPittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-2482-080X
Patrick J PaganoPittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-7475-808X

Funding

PREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM008424 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1994 to 2005
$915k
Platelet Metabolic Stress Induces Thrombo-Inflammation to Drive Endothelial Dysfunction in PHR01HL166985 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$721k
NOX2 Small Molecule Inhibitors as a Therapeutic Strategy in the Treatment of Alzheimer’s DiseaseR21AG089718 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$239k
Predoctoral Training in Pharmacological SciencesT32GM133332 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$213k
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2020/12432-6HHS | National Institutes of Health (NIH) T32GM133332-02HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL166985-01A1HHS | NIH | NHLBI | Division of Intramural Research (DIR) R01HL142248-04NHLBI NIH HHS R01 HL142248NHLBI NIH HHS R01 HL166985NIA NIH HHS R21 AG089718NIGMS NIH HHS T32 GM008424NIGMS NIH HHS T32 GM133332University of Pittsburgh (Pitt) Vitalant & Western PA Blood Bank
6 · The paper itself

Abstract

The redox signaling network in mammals has garnered enormous interest and taken on major biological significance in recent years as the scope of NADPH oxidases (NOXs) as regulators of physiological signaling and cellular degeneration has grown exponentially. All NOX isoforms have in common the capacity to generate reactive oxygen species (ROS) superoxide anion (O

Indexed as

HomeostasisNADPH OxidasesAnimalsHumansOxidation-ReductionReactive Oxygen SpeciesSignal TransductionNADPH OxidasesReactive Oxygen SpeciesdiseaseNADPH oxidaseNOXphysiologyredox signaling

Identifiers

PMID39814410
PMCPMC12285607

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.