Evidence map›Paper›PMID 39815082›Full record

ArticleScientific reports2025

The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice.

Tess Yntema, Tim R Eijgenraam, Niels J Kloosterhuis, Rick Havinga, Mirjam H Koster, Milaine V Hovingh, Jan Freark de Boer, Debby P Y Koonen, Folkert Kuipers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tess YntemaDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Tim R EijgenraamDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Niels J KloosterhuisDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Rick HavingaDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Mirjam H KosterDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Milaine V HovinghDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jan Freark de BoerDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Debby P Y Koonen *Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. d.p.y.koonen@umcg.nl.
Folkert Kuipers *Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Funding

This work was funded by the Netherlands Heart Foundation to F. Kuipers and D. Koonen IN-CONTROL II, CVON grant 2018-27
6 · The paper itself

Abstract

Bile acids (BAs) play important roles in the context of lipid homeostasis and inflammation. Based on extensive preclinical mouse studies, BA signaling pathways have been implicated as therapeutic targets for cardiovascular diseases. However, differences in BA metabolism between mice and humans hamper translation of preclinical outcomes. Recently, we generated Cyp2c70

Indexed as

AtherosclerosisBile Acids and SaltsCytochrome P450 Family 2HypercholesterolemiaAnimalsCholesterolDiet, WesternDisease Models, AnimalHumansLiverMaleMiceMice, KnockoutProprotein Convertase 9TriglyceridesBile Acids and SaltsCholesterolCytochrome P450 Family 2Proprotein Convertase 9Triglycerides

Identifiers

PMID39815082
PMCPMC11735988

What Socratic holds

Texttitle and abstract
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.