ArticleBMC musculoskeletal disorders2025
Medium- to long-term functional outcomes of artcure diffusional patch therapy for lumbar disc herniation: which herniation is more likely to require surgery?
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Combined pulse radiofrequency and selective nerve root block for lumbar disc herniation-related neuropathic pain: a retrospective cohort study.Frontiers in medicine · 2026Article
- Efficacy of Selective Nerve Root Block for Different Types of Lumbar Disc Herniation: Study Protocol for a Single-Blind, Prospective Cohort Study.Journal of pain research · 2025Article
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Authors and funding
4 authors.
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Abstract
backgroundArtcure diffusional patch (ADP) is a novel transdermal therapeutic system that started to be used in the last decade for lumbar disc herniation (LDH). Previous studies have reported early results of the therapy. In this study, we aimed to evaluate the medium- to long-term functional outcomes of this treatment in LDH patients and examine factors predicting the need for surgery after treatment.
methodsTotally, 270 patients with single-level LDH were included. ADP was applied transdermally to the lumbar regions of the patients. Outcomes measures included the Oswestry Disability Index (ODI) and leg and low back visual analog scales (VAS). Herniations were graded using the Michigan State University (MSU) classification. The predictive factors for surgery need were analyzed with logistic regression analysis.
resultsThe average follow-up duration was 43.8 ± 4.8 months. The average VAS and ODI scores of the patients decreased significantly at the first month and final visits compared to admission values (p < 0.001). Within the follow-up period, 19 (7.0%) patients underwent surgery. The results of the multivariate analysis showed that ≥ 2 MSU grade of the herniation was a significant predictive factor for operation need (HR: 7.32 (1.87-28.57), p = 0.004).
conclusionSingle-dose ADP therapy is a safe and feasible treatment option in the treatment of single-level LDH and can achieve favorable functional and pain scores at medium- to long-term. Patients with MSU grade two and three herniations should be monitored more closely, as they are more likely to experience a later surgical intervention. CLINICAL TRIAL NUMBER: Not applicable.
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