ArticleDiabetology & metabolic syndrome2025
Triglyceride glucose index-body mass index as a predictor of coronary artery disease severity in patients with H-type hypertension across different glucose metabolic states.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Association between the triglyceride-glucose-body mass index and the risk of early vascular aging in young and middle-aged Chinese adults: a cross-sectional study.BMC cardiovascular disorders · 2026Observational
- C-reactive protein-triglyceride glucose index for the detection of the severity of coronary artery disease in different glucose metabolic states in patients with H-type hypertension.Cardiovascular diabetology · 2026Article
- Amlodipine Besylate-Folic Acid demonstrates superior efficacy to Enalapril Maleate-Folic Acid in treating H-type hypertension.American journal of translational research · 2026Article
- Association Between Triglyceride-Glucose-Body Mass Index and Depression in Elderly Diabetic Individuals: A Population-Based Study.International journal of endocrinology · 2026Article
- Evaluating Body Mass Index to High-Density Lipoprotein Cholesterol (BMI/HDL-C) Ratio in Predicting Coronary Artery Disease: A Multicenter Study.Vascular health and risk management · 2026Observational
- Higher Dietary Insulinemic Potential, and Triglyceride-Glucose (TyG)-BMI Index may Contribute to Coronary Artery Disease Severity: a Cross-Sectional Study.Journal of epidemiology and global health · 2025Article
- Interaction between triglyceride-glucose-body mass index and age in coronary artery stenosis severity: a sex-stratified exploratory analysis.BMC cardiovascular disorders · 2025Article
- Surrogate markers of insulin resistance and coronary artery disease in type 2 diabetes: U-shaped TyG association and insights from machine learning integration.Lipids in health and disease · 2025Article
- Understanding triglyceride glucose-body mass index: implications for diabetes and cardiovascular disease management.Frontiers in endocrinology · 2025Review
- Triglyceride glucose-body mass index is associated with diabetic kidney disease in type 2 diabetes mellitus patients without non-alcoholic fatty liver disease.Frontiers in nutrition · 2025Article
- Association between triglyceride-glucose index and the risk of stroke among moyamoya patients: a single-center retrospective study.Frontiers in neurology · 2025Article
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5 authors.
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Abstract
backgroundThe triglyceride glucose-body mass index (TyG-BMI) is considered to be a reliable surrogate marker of insulin resistance (IR). However, limited evidence exists regarding its association with the severity of coronary artery disease (CAD), particularly in hypertensive patients with different glucose metabolic states, including those with H-type hypertension. This study aimed to investigate the relationship between TyG-BMI and CAD severity across different glucose metabolism conditions.
methodsThis retrospective cohort study included 1537 hypertensive patients who underwent coronary angiography. The TyG-BMI was categorized into tertiles and analyzed using logistic regression models and restricted cubic spline (RCS) models to assess its association with multi-vessel CAD. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of TyG-BMI in detecting the severity of CAD in different glucose metabolism states, including normal glucose regulation (NGR), pre-diabetes mellitus (Pre-DM), and diabetes mellitus (DM). The above method has also been applied to populations of H-type hypertension patients.
resultsThe TyG-BMI was significantly associated with the severity of multi-vessel CAD in hypertensive patients (Odds ratio [OR] 1.043, 95% CI 1.032-1.053). In the diabetic subgroup, after adjusting for risk factors, the risk of multi-vessel CAD in the T3 groups was 3.836-fold (95% CI 1.763-8.347; P = 0.001) higher than in the T1 group, with a non-linear dose-response relationship (P for non-linearity = 0.017). In H-type hypertension patients, the TyG-BMI was also significantly correlated with multi-vessel CAD (OR 5.248, 95% CI 1.821-15.126, P = 0.002) in the DM group. The ROC analysis revealed that TyG-BMI had the highest predictive value for multi-vessel CAD in diabetic patients, with an AUC of 0.720 (95% CI 0.661-0.780, P < 0.001).
conclusionsThe TyG-BMI serves as a robust predictor of CAD severity in hypertensive patients, particularly those with diabetes and H-type hypertension. And the non-linear dose-response relationship between TyG-BMI and multi-vessel CAD in diabetic patients underscores its potential clinical utility. This index could serve as a valuable tool for the early identification of individuals at high risk.
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