Evidence map›Paper›PMID 39815613›Full record

ArticleJournal of Zhejiang University. Science. B2024

CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels.

Ru He, Hongyi Jiang, Chengchi Zhang, Yuan Chen, Wenshun Liu, Xinyue Deng, Xiaozheng Zhu, Yunye Liu, Chuanming Zheng, Yining Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ru HeOtolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Hongyi JiangOtolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Chengchi ZhangCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Yuan ChenCancer Center, Department of Pathology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Wenshun LiuDepartment of Postgraduate Education, Jinzhou Medical University, Jinzhou 121000, China.
Xinyue DengOtolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Xiaozheng ZhuOtolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Yunye LiuOtolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Chuanming ZhengOtolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.
Yining ZhangThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Chengying ShaoThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yanting DuanOtolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China. dyt19880818@163.com.
Jiajie XuOtolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China. dyt19880818@163.com, xujiajie@hmc.edu.cn.

Funding

the Key Research and Development Program of Zhejiang Province 2024C03166the Scientific Research Fund of the National Health Commission-Zhejiang Provincial Health Major Science and Technology Plan Project WKJ-ZJ-2415the Traditional Chinese Medicine Science and Technology Project of Zhejiang Province 2022ZB020the Zhejiang Provincial Natural Science Foundation of China LY21H160049
6 · The paper itself

Abstract

Numerous studies have demonstrated that the high expression of CXC motif chemokine ligand 16 (CXCL16) in cancer correlates with poor prognosis, as well as tumor cell proliferation, migration, and invasion. While CXCL16 can serve as a tumor biomarker, the underlying mechanism in modulating head and neck squamous cell carcinoma (HNSCC) remains unclear. In this study, the aimed was to investigate the CXCL16 expression in HNSCC and to uncover the potential underlying mechanism. Hereby, we determined the high expression of CXCL16 in The Cancer Genome Atlas (TCGA) database, as well as in tissue samples from patients with HNSCC at our central hospital and from HNSCC cell lines. The results showed that

Indexed as

AntioxidantsChemokine CXCL16Glutathione PeroxidaseHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticGlutathione Peroxidase GPX1HumansNeoplasm InvasivenessReactive Oxygen SpeciesAntioxidantsChemokine CXCL16CXCL16 protein, humanGlutathione PeroxidaseGlutathione Peroxidase GPX1GPX1 protein, humanReactive Oxygen SpeciesAntioxidant pathwayCXC motif chemokine ligand 16 (CXCL16)Glutathione peroxidase 1 (GPX1)Head and neck squamous cell carcinoma (HNSCC)

Identifiers

PMID39815613
PMCPMC11735913

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.