Evidence map›Paper›PMID 39817552›Full record

ArticleJournal of the American Heart Association2025

Carotid Endarterectomy Ameliorates Cognitive Impairment in Clinical and Experimental Unilateral Carotid Artery Stenosis.

Yijun Cheng, Bin Chen, Miao Zhang, Zhenghong Chen, Mingjian Liu, Ziqian Zhang, Hao Tang, Dapeng Wang, Wenwen Lv, Biao Li and 2 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A review of animal models of vascular dementia.Molecular biology reports · 2026
    Review
  2. Article
  3. Article
  4. The Glymphatic System and Its Role in Neurovascular Diseases.Journal of neuroendovascular therapy · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yijun ChengDepartment of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.ORCID 0000-0001-9720-738X
Bin ChenDepartment of Neurosurgery, Ruijin Hospital Luwan Branch Shanghai Jiao Tong University School of Medicine Shanghai China.ORCID 0000-0001-7351-3972
Miao ZhangDepartment of Nuclear Medicine, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Zhenghong ChenDepartment of Neurosurgery, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Mingjian LiuDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College Fudan University Shanghai China.
Ziqian ZhangDepartment of Neurosurgery, Xuanwu Hospital Capital Medical University Beijing China.ORCID 0000-0002-0706-3042
Hao TangDepartment of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.ORCID 0000-0003-2053-2066
Dapeng WangDepartment of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.ORCID 0000-0001-5213-4949
Wenwen LvClinical Research Center, School of Medicine Shanghai Jiao Tong University Shanghai China.
Biao LiDepartment of Nuclear Medicine, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.ORCID 0000-0002-0493-2062
Yuting DaiShanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.ORCID 0000-0001-8275-2115
Hanbing ShangDepartment of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.ORCID 0000-0001-7815-2758

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCarotid endarterectomy (CEA) is widely used to treat carotid artery stenosis (CAS). However, the effects of CEA on unilateral CAS-induced cognitive impairment and the underlying mechanism remain poorly understood. METHODS AND

resultsThirteen patients diagnosed with unilateral severe CAS underwent pre- and post-CEA assessments, including

conclusionsCEA ameliorated CAS-induced cognitive dysfunction by improving the cerebral functional structure. These beneficial effects may be attributed to their antioxidant and anti-inflammatory properties.

Indexed as

Carotid StenosisCognitionCognitive DysfunctionEndarterectomy, CarotidAgedAnimalsCerebrovascular CirculationDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMiddle AgedNF-E2-Related Factor 2White MatterNF-E2-Related Factor 2carotid artery stenosiscarotid endarterectomycognitive impairmentgenomic sequencingPET/MRwhite blood cell

Identifiers

PMID39817552
PMCPMC12054441

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.