Evidence map›Paper›PMID 39818939›Full record

ArticleJournal of medicinal chemistry2025

Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2

Andrea Bagán, Alba López-Ruiz, Sònia Abás, M Carmen Ruiz-Cantero, Foteini Vasilopoulou, Teresa Taboada-Jara, Christian Griñán-Ferré, Mercè Pallàs, Carolina Muguruza, Rebeca Diez-Alarcia and 21 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Usefulness ofInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Andrea BagánLaboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain.
Alba López-RuizLaboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain.
Sònia AbásLaboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain.
M Carmen Ruiz-CanteroLaboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain.
Foteini VasilopoulouPharmacology Section, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institut de Neurociències, University of Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain.
Teresa Taboada-JaraPharmacology Section, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institut de Neurociències, University of Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain.
Christian Griñán-FerréPharmacology Section, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institut de Neurociències, University of Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain.ORCID 0000-0002-5424-9130
Mercè PallàsPharmacology Section, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institut de Neurociències, University of Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain.ORCID 0000-0003-3095-4254
Carolina MuguruzaDepartment of Pharmacology, University of the Basque Country, UPV/EHU48940 Leioa, Bizkaia.
Rebeca Diez-AlarciaDepartment of Pharmacology, University of the Basque Country, UPV/EHU48940 Leioa, Bizkaia.
Luis F CalladoDepartment of Pharmacology, University of the Basque Country, UPV/EHU48940 Leioa, Bizkaia.
José M EntrenaAnimal Behavior Research Unit, Scientific Instrumentation Center, Parque Tecnológico de la Salud, University of Granada, Armilla, Granada 18100, Spain.
Enrique J CobosDepartment of Pharmacology, Faculty of Medicine and Biomedical Research Center (Neurosciences Institute), Biosanitary Research Institute ibs.GRANADA, University of Granada, Granada 18016, Spain.
Belén PérezDepartment of Pharmacology, Therapeutic and Toxicology. Autonomous, University of Barcelona, Cerdanyola 08193, Spain.
José A Morales-GarcíaDepartment of Cell Biology. Faculty of Medicine, Computense University of Madrid. (UCM), Madrid 28040, Spain.
Elies MolinsInstitut de Ciencia de Materials de Barcelona (CSIC), Campus UAB, Cerdanyola 08193, Spain.ORCID 0000-0003-1012-0551
Steven De JongheMolecular, Structural and Translational Virology Research Group, Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven 3000, Belgium.ORCID 0000-0002-3872-6558
Dirk DaelemansMolecular Genetics and Therapeutics in Virology and Oncology Research Group, Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven 3000, Belgium.
José BreaDrug Screening Platform/Biofarma Research Group, CIMUS Research Center, University of Santiago de Compostela (USC), Santiago de Compostela 15782, Spain.ORCID 0000-0002-5523-1979
Cristina ValDrug Screening Platform/Biofarma Research Group, CIMUS Research Center, University of Santiago de Compostela (USC), Santiago de Compostela 15782, Spain.
M Isabel LozaDrug Screening Platform/Biofarma Research Group, CIMUS Research Center, University of Santiago de Compostela (USC), Santiago de Compostela 15782, Spain.ORCID 0000-0003-4730-0863
Elena Hernández-HernándezIUNICS, University of the Balearic Islands (UIB) and IdISBa, Cra. Valldemossa km 7.5, Palma de Mallorca 07122, Spain.
Jesús A García-SevillaIUNICS, University of the Balearic Islands (UIB) and IdISBa, Cra. Valldemossa km 7.5, Palma de Mallorca 07122, Spain.
M Julia García-FusterIUNICS, University of the Balearic Islands (UIB) and IdISBa, Cra. Valldemossa km 7.5, Palma de Mallorca 07122, Spain.
Caridad DíazFundación MEDINA Centro de Excelencia en Investigación de Medicamentos Innovadores de Andalucía, Avda. Del Conocimiento 34, Ganada 10016, Spain.
Rosario Fernández-GodinoFundación MEDINA Centro de Excelencia en Investigación de Medicamentos Innovadores de Andalucía, Avda. Del Conocimiento 34, Ganada 10016, Spain.
Olga GenilloudFundación MEDINA Centro de Excelencia en Investigación de Medicamentos Innovadores de Andalucía, Avda. Del Conocimiento 34, Ganada 10016, Spain.ORCID 0000-0002-4202-1219
Milan BeljkašDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, Belgrade 11000, Serbia.
Slavica OljačićDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, Belgrade 11000, Serbia.
Katarina NikolicDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, Belgrade 11000, Serbia.
Carmen EscolanoLaboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain.ORCID 0000-0002-9117-8239

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imidazoline

Indexed as

Alzheimer DiseaseAnalgesicsImidazoline ReceptorsOrganophosphonatesAnimalsDrug DiscoveryHumansLigandsMaleMiceStructure-Activity RelationshipAnalgesicsimidazoline receptor 2Imidazoline ReceptorsLigandsOrganophosphonates

Identifiers

PMID39818939
PMCPMC11831594

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.