Evidence map›Paper›PMID 39821326›Full record

Trial reportJournal of pineal research2025

Resetting of the Human Circadian Melatonin Rhythm by Ambient Hypoxia.

Titiaan E Post, Riccardo De Gioannis, Jan Schmitz, Martin Wittkowski, Tina Martin Schäper, Anna Wrobeln, Joachim Fandrey, Marie-Therese Schmitz, Joseph S Takahashi, Jens Jordan and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pineal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Titiaan E PostInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.ORCID http://orcid.org/0000-0002-4844-6402
Riccardo De GioannisInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.
Jan SchmitzInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.ORCID https://orcid.org/0000-0003-0282-097X
Martin WittkowskiInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.ORCID https://orcid.org/0009-0008-5854-4445
Tina Martin SchäperInstitute of Physiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0009-0005-2530-2851
Anna WrobelnInstitute of Physiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0003-1792-0391
Joachim FandreyInstitute of Physiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0001-9585-0531
Marie-Therese SchmitzInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.ORCID https://orcid.org/0000-0003-1351-9381
Joseph S TakahashiDepartment of Neuroscience, Peter O'Donnell Jr Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0003-0384-8878
Jens JordanInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.ORCID https://orcid.org/0000-0003-4518-0706
Eva-Maria ElmenhorstInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.ORCID https://orcid.org/0000-0003-0336-6705
Daniel AeschbachInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.ORCID https://orcid.org/0000-0002-6054-5753

Funding

The study was supported through funds from the Aeronautics Program and Space Program of the German Aerospace Center.
6 · The paper itself

Abstract

Circadian clocks in the body drive daily cycles in physiology and behavior. A master clock in the brain maintains synchrony with the environmental day-night cycle and uses internal signals to keep clocks in other tissues aligned. Work in cell cultures uncovered cyclic changes in tissue oxygenation that may serve to reset and synchronize circadian clocks. Here we show in healthy humans, following a randomized controlled single-blind counterbalanced crossover study design, that one-time exposure to moderate ambient hypoxia (FiO

Indexed as

Circadian RhythmHypoxiaMelatoninAdultCross-Over StudiesFemaleHumansMaleSingle-Blind MethodMelatonincircadian clockshumanshypoxiahypoxia‐inducible factorsmelatoninoxygenphase shifting

Identifiers

PMID39821326
PMCPMC11740168

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.