Evidence map›Paper›PMID 39822165›Full record

Observational studyJournal of clinical hypertension (Greenwich, Conn.)2025

Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India.

Thomas Alexander, Jagdish S Hiremath, Jitendra P S Swahney, Subhash Chandra, Peeyush Jain, Praveen Chandra, Nakul Sinha, T Sashikanth, Yugandhar Bachhu, Anil Balachandran and 15 more

Abstract readObservational Study
In one paragraph

Observational study in Journal of clinical hypertension (Greenwich, Conn.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Thomas AlexanderDepartment of Interventional Cardiology, Kovai Medical Center and Hospital, Coimbatore, Tamil Nadu, India.
Jagdish S HiremathDepartment of Interventional Cardiology, Ruby Hall Clinic, Pune, Maharashtra, India.
Jitendra P S SwahneyDepartment of Cardiology, Sir Ganga Ram Hospital, New Delhi, India.
Subhash ChandraDepartment of Interventional Cardiology - Cardiology & Structural Heart Disease, Blk-Max Super Speciality Hospital, New Delhi, India.
Peeyush JainDepartment of Preventive Cardiology, Fortis Hospital Delhi, New Delhi, India.
Praveen ChandraDepartment of Interventional Cardiology, Cardiac Care, Medanta Medicity, Gurgaon, India.
Nakul SinhaDepartment of Interventional Cardiology, Medanta Heart Institute, Lucknow, Uttar Pradesh, India.
T SashikanthDepartment of Interventional Cardiology, Yashoda Hospitals, Secunderabad, Telangana, India.
Yugandhar BachhuDepartment of Interventional Cardiology, Tirupati, Andhra Pradesh, India.
Anil BalachandranDepartment of Interventional Cardiology, Lakshmi Hospital, Cochin, Kerala, India.
Pathiyil Balagopalan JayagopalDepartment of Cardiology, Lakshmi Hospital, Palakkad, Kerala, India.
T Govindan UnniDepartment of Cardiology, Jubilee Mission Medical College & Research Institute, Thrissur, Kerala, India.
Tiny NairDepartment of Cardiology, PRS Hospital, Killipalam, Trivandrum, Kerala, India.
Kumaresan KannanDepartment of Cardiology, Aswene Soundra Hospital and Research Centre, Chennai, India.
Dorairaj PrabhakarDepartment of Interventional Cardiology, Apollo Firstmed Hospital, Consultant Cardiologist, Ashwin Clinic, Chennai, India.
M ChenniappanIMA College of General Practitioners, Trichy, India.
Ajay U MahajanDepartment of Cardiology, G.S. Medical College & K.E.M Hospital, Mumbai, USA.
Rajiv D KarnikDepartment of Interventional Cardiology, Cath Interventions, Fortis Hospital, Mumbai, Maharashtra, India.
Chandrashekhar K PondeDepartment of Cardiology, Hinduja Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
Prashant AdvaniDepartment of Cardiology, Advani Heartline, Raipur, Chhattisgarh, India.
Idris Ahmed KhanDepartment of Interventional Cardiology, Bombay Hospital, Indore, Madhya Pradesh, India.
Brij Mohan GoyalCardiac Science Apex Hospital, Jaipur, Rajasthan, India.
P R VaidyanathanDepartment of Cardiology, Hindusthan Hospital, Coimbatore, Tamil Nadu, India.
Hiren PrajapatiDepartment of Medical Affairs, Eris Lifesciences Ltd., Ahmedabad, Gujarat, India.
Willem J VerberkCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0003-2230-0488

Funding

Eris Life Sciences Ltd
6 · The paper itself

Abstract

This study evaluated initial antihypertensive drug prescription patterns in Indian healthcare settings. An observational, cross-sectional, prospective prescription registry analyzed prescriptions for 4723 newly diagnosed hypertension patients. Additionally, it investigated the extent to which physicians adhered to either European or Indian hypertension guidelines. Angiotensin receptor blockers (ARBs) were the most commonly prescribed drugs, given to 79% of patients, followed by calcium channel blockers (CCBs) at 55%. Diuretics and beta-blockers (BBs) were prescribed to 27% and 17% of patients, respectively. Monotherapy was administered to 35% of patients, while combination therapies were more prevalent, with dual therapy at 51% and regimens involving three or more drugs prescribed to 14%. Among multi-drug treatments (n = 3082, 65%), 98% received fixed-dose combination tablets. The most common combinations were ARB + CCB (26%), ARB + diuretic (12%), and ARB + CCB + diuretic (8%). Key predictors for an increasing number of prescribed drugs included statin use/dyslipidemia, age, blood pressure level, and diabetes. Non-adherence to hypertension guidelines was evident as 1364 patients classified from moderate to very high risk received monotherapy. Of these, 496 patients had grade 2 or 3 hypertension. Additionally, 88 patients received the undesirable combination of ACEi + ARB, and 267 (15.9%) type 2 diabetes mellitus (T2DM) patients did not receive RAS-blockers (146 on monotherapy). The findings reveal a trend toward utilizing ARBs, CCBs, and combination tablets, indicating improved adherence to guidelines. However, a significant number of patients did not receive appropriate treatment, highlighting areas for improvement in prescription practices.

Indexed as

Antihypertensive AgentsDrug PrescriptionsHypertensionPractice Patterns, Physicians'Adrenergic beta-AntagonistsAdultAgedAngiotensin Receptor AntagonistsCalcium Channel BlockersCross-Sectional StudiesDiureticsDrug Therapy, CombinationFemaleGuideline AdherenceHumansIndiaAdrenergic beta-AntagonistsAngiotensin Receptor AntagonistsAntihypertensive AgentsCalcium Channel BlockersDiureticsantihypertensive therapyclinical management of high blood pressure (HBP)clinical pharmacologycombination therapyepidemiology

Identifiers

PMID39822165
PMCPMC11771799

What Socratic holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.